Seroatlas · Human Serome Atlas

C15orf62

Uncharacterized protein C15orf62, mitochondrial

Also known as: CO062_HUMAN, LOC643338

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8K5M9
Gene: C15orf62
Ensembl: ENSG00000188277
Chromosome: 15
Canonical length: 175 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable small GTPase binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of cellular component biogenesis; and regulation of cell shape. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

175 residues, UniProt reviewed canonical sequence.

>A8K5M9|C15orf62
     1  METWRKGSFR NASFFKQLSL GRPRRLRRQS SVLSQASTAG GDHEEYSNRE VIRELQGRPD
    61  GRRLPLWGDE QPRATLLAPP KPPRLYRESS SCPNILEPPP AYTAAYSATL PSALSLSSAL
   121  HQHSEKGLVD TPCFQRTPTP DLSDPFLSFK VDLGISLLEE VLQMLREQFP SEPSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C15orf62 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

esophagus: 25 nTPM
skin: 17 nTPM
salivary gland: 7.9 nTPM
vagina: 6.5 nTPM
cerebellum: 5.7 nTPM
cervix: 5.6 nTPM

Single-cell type

esophageal apical cells: 283 nCPM
ocular epithelial cells: 13 nCPM
submucosal glandular cells: 12 nCPM
endometrial secretory cells: 12 nCPM
endometrial glandular cells: 9.9 nCPM
respiratory secretory cells: 9.6 nCPM

Immune cell

memory CD4 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 16 nTPM
cerebral cortex: 10 nTPM
white matter: 9.3 nTPM
pons: 8.8 nTPM
thalamus: 8.8 nTPM
basal ganglia: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0.03
gnomAD missense Z: 1.06
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

small GTPase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cdc42 Effector Protein BORG/CEP

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C15orf62 as an antibody target. Whether an autoantibody or antibody against C15orf62 could matter depends on whether native C15orf62 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C15orf62 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C15orf62 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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