C15orf61
Uncharacterized protein C15orf61
Also known as: CO061_HUMAN, LOC145853
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NNL5
- Gene
- C15orf61
- Ensembl
- ENSG00000189227
- Chromosome
- 15
- Canonical length
- 157 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Nucleoli,Vesicles,Cytosol
- Secretome location
- Secreted - unknown location
OverviewNCBI Gene
Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
157 residues, UniProt reviewed canonical sequence.
>A6NNL5|C15orf61
1 MEALRRAHEV ALRLLLCRPW ASRAAARPKP SASEVLTRHL LQRRLPHWTS FCVPYSAVRN
61 DQFGLSHFNW PVQGANYHVL RTGCFPFIKY HCSKAPWQDL ARQNRFFTAL KVVNLGIPTL
121 LYGLGSWLFA RVTETVHTSY GPITVYFLNK EDEGAMYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C15orf61 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 22 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 22 nTPM
- retina: 10 nTPM
- cerebellum: 8.8 nTPM
- tongue: 7.7 nTPM
- testis: 7.4 nTPM
- basal ganglia: 6.5 nTPM
Single-cell type
- late primary spermatocytes: 547 nCPM
- oocytes: 415 nCPM
- early spermatids: 174 nCPM
- undifferentiated spermatogonia: 81 nCPM
- epididymal principal cells: 75 nCPM
- esophageal basal cells: 71 nCPM
Immune cell
- eosinophil: 7.9 nTPM
- basophil: 7.7 nTPM
- naive CD4 T-cell: 6.2 nTPM
- memory CD4 T-cell: 6 nTPM
- memory B-cell: 5.3 nTPM
- MAIT T-cell: 5.2 nTPM
Brain region
- cerebellum: 23 nTPM
- basal ganglia: 21 nTPM
- cerebral cortex: 17 nTPM
- hippocampal formation: 15 nTPM
- midbrain: 13 nTPM
- amygdala: 13 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.32
- gnomAD pLI
- 0.09
- gnomAD missense Z
- -0.13
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4528
- Domain of unknown function (DUF4528)
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C15orf61 as an antibody target. Whether an autoantibody or antibody against C15orf61 could matter depends on whether native C15orf61 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C15orf61 is annotated as secreted, so native C15orf61 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label C15orf61 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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