Seroatlas · Human Serome Atlas

C15orf40

UPF0235 protein C15orf40

Also known as: CO040_HUMAN, MGC29937

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WUR7
Gene
C15orf40
Ensembl
ENSG00000169609
Chromosome
15
Canonical length
153 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>Q8WUR7|C15orf40
     1  MLRLRSGLRH LRATPNTRGS ARLLCAEMPK KAGATTKGKS QSKEPERPLP PLGPVAVDPK
    61  GCVTIAIHAK PGSKQNAVTD LTAEAVNVAI AAPPSEGEAN AELCRYLSKV LELRKSDVVL
   121  DKGGKSREKV VKLLASTTPE EILEKLKKEA KKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C15orf40 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 19 nTPM
  • bone marrow: 18 nTPM
  • kidney: 17 nTPM
  • skin: 14 nTPM
  • testis: 14 nTPM
  • adipose tissue: 13 nTPM

Single-cell type

  • early primary spermatocytes: 99 nCPM
  • late primary spermatocytes: 90 nCPM
  • epididymal principal cells: 90 nCPM
  • enterocytes: 72 nCPM
  • esophageal apical cells: 66 nCPM
  • esophageal suprabasal cells: 65 nCPM

Immune cell

  • basophil: 59 nTPM
  • memory B-cell: 47 nTPM
  • NK-cell: 42 nTPM
  • T-reg: 41 nTPM
  • naive B-cell: 39 nTPM
  • naive CD4 T-cell: 34 nTPM

Brain region

  • white matter: 50 nTPM
  • cerebellum: 46 nTPM
  • cerebral cortex: 43 nTPM
  • medulla oblongata: 38 nTPM
  • basal ganglia: 37 nTPM
  • hippocampal formation: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0.19
gnomAD missense Z
-0.63
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF167
  • YggU-like superfamily
  • Uncharacterised ACR, YggU family COG1872

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C15orf40 as an antibody target. Whether an autoantibody or antibody against C15orf40 could matter depends on whether native C15orf40 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C15orf40 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C15orf40 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C15orf40. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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