C15orf32
Uncharacterized protein C15orf32
Also known as: CO032_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for C15orf32 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
178 residues, UniProt reviewed canonical sequence.
>Q32M92|C15orf32
1 MNKRTSVDAS KEDLHPADPQ SGEGVPPNRK NTKTSPRGEG TAPPFSARPC VWTLCEMLSI
61 LALVGVLHPF YRSNNQVYQK LKTHLRCQSS RVDGLMLKPT LLTPSQLKSP EGHLILPTFN
121 HLVIRHILDP KQIFCVADVC TDCKFNCGSI ERHQKRHLMR VSQDWEHLIR YRNQICLSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C15orf32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.53
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.1
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C15orf32 as an antibody target. Whether an autoantibody or antibody against C15orf32 could matter depends on whether native C15orf32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C15orf32 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C15orf32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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