Seroatlas · Human Serome Atlas

C14orf132

Uncharacterized protein C14orf132

Also known as: C14orf88, CN132_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NPU4
Gene
C14orf132
Ensembl
ENSG00000227051
Chromosome
14
Canonical length
83 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

83 residues, UniProt reviewed canonical sequence.

>Q9NPU4|C14orf132
     1  MDLSFMAAQL PMMGGAFMDS PNEDFSTEYS LFNSSANVHA AANGQGQPED PPRSSNDAVL
    61  LWIAIIATLG NIVVVGVVYA FTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C14orf132 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
108 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 108 nTPM
  • hippocampal formation: 91 nTPM
  • amygdala: 79 nTPM
  • cerebral cortex: 78 nTPM
  • spinal cord: 64 nTPM
  • hypothalamus: 55 nTPM

Single-cell type

  • fallopian tube ciliated cells: 122 nCPM
  • alveolar cells type 1: 118 nCPM
  • lactotrophs: 109 nCPM
  • somatotrophs: 107 nCPM
  • adrenal medulla cells: 75 nCPM
  • thyrotrophs: 73 nCPM

Immune cell

  • naive CD4 T-cell: 0.9 nTPM
  • memory CD4 T-cell: 0.4 nTPM
  • naive B-cell: 0.2 nTPM
  • total PBMC: 0.2 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM

Brain region

  • hippocampal formation: 132 nTPM
  • cerebral cortex: 116 nTPM
  • cerebellum: 105 nTPM
  • basal ganglia: 95 nTPM
  • thalamus: 95 nTPM
  • amygdala: 94 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.64

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C14orf132 as an antibody target. Whether an autoantibody or antibody against C14orf132 could matter depends on whether native C14orf132 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C14orf132 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C14orf132 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C14orf132. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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