Seroatlas · Human Serome Atlas

C14orf119

Uncharacterized protein C14orf119

Also known as: CN119_HUMAN, FLJ20671

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWQ9
Gene: C14orf119
Ensembl: ENSG00000179933
Chromosome: 14
Canonical length: 140 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>Q9NWQ9|C14orf119
     1  MPLESSSSMP LSFPSLLPSV PHNTNPSPPL MSYITSQEMK CILHWFANWS GPQRERFLED
    61  LVAKAVPEKL QPLLDSLEQL SVSGADRPPS IFECQLHLWD QWFRGWAEQE RNEFVRQLEF
   121  SEPDFVAKFY QAVAATAGKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C14orf119 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 59 nTPM
adrenal gland: 48 nTPM
rectum: 48 nTPM
tonsil: 48 nTPM
spleen: 47 nTPM
esophagus: 46 nTPM

Single-cell type

syncytiotrophoblasts: 191 nCPM
esophageal apical cells: 189 nCPM
decidual stromal cells: 160 nCPM
hofbauer cells: 145 nCPM
extravillous trophoblasts: 144 nCPM
esophageal suprabasal cells: 140 nCPM

Immune cell

basophil: 318 nTPM
eosinophil: 304 nTPM
total PBMC: 203 nTPM
T-reg: 189 nTPM
classical monocyte: 161 nTPM
myeloid DC: 151 nTPM

Brain region

choroid plexus: 34 nTPM
white matter: 29 nTPM
thalamus: 28 nTPM
pons: 25 nTPM
medulla oblongata: 25 nTPM
cerebellum: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0.01
gnomAD missense Z: 0.46
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4508
Domain of unknown function (DUF4508)

KeywordsUniProt

Mitochondrion

InteractionsUniProt · HPA

Protein binding partners of C14orf119 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ACTN1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C14orf119 as an antibody target. Whether an autoantibody or antibody against C14orf119 could matter depends on whether native C14orf119 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C14orf119 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C14orf119 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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