Seroatlas · Human Serome Atlas

C13orf46

Uncharacterized protein C13orf46

Also known as: CM046_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GUA9
Gene
C13orf46
Ensembl
ENSG00000283199
Chromosome
13
Canonical length
212 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C13orf46 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

212 residues, UniProt reviewed canonical sequence.

>A0A1B0GUA9|C13orf46
     1  MEKDTGTTHR RHRPGLRALP SGVALGHLKA ASEASELQRS RSLGGLQPEG DPPSRPRKPH
    61  KELESEDQGK DPSSNAEDAS CQKNLAQDKK ESFSTLGKLG HESGKQDPER EKSDLEASMQ
   121  EVQEGEHADG GLQEAKEQEA ESIKLNDLQE EEKASVFVEI DLGDHAEEVV TDAKKEEKPS
   181  QMDVEDLSED EMQTSWVCCI PYSTRKRAKE ST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C13orf46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.73
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • testis: 12 nTPM
  • pancreas: 8.7 nTPM
  • stomach: 6.1 nTPM
  • lung: 2.3 nTPM
  • thyroid gland: 2.2 nTPM
  • adipose tissue: 1.1 nTPM

Single-cell type

  • late spermatids: 25 nCPM
  • early spermatids: 11 nCPM
  • late primary spermatocytes: 4.6 nCPM
  • choroid plexus epithelial cells: 3 nCPM
  • microglia: 2.9 nCPM
  • ependymal cells: 2.3 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 4.8 nTPM
  • white matter: 3.3 nTPM
  • midbrain: 2.7 nTPM
  • cerebral cortex: 2.6 nTPM
  • hippocampal formation: 2.5 nTPM
  • thalamus: 2.3 nTPM

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterized protein C13orf46-like

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C13orf46 as an antibody target. Whether an autoantibody or antibody against C13orf46 could matter depends on whether native C13orf46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C13orf46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C13orf46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C13orf46. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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