Seroatlas · Human Serome Atlas

C13orf42

Uncharacterized protein C13orf42

Also known as: CM042_HUMAN, LINC00371

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVH6
Gene
C13orf42
Ensembl
ENSG00000226792
Chromosome
13
Canonical length
325 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C13orf42 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>A0A1B0GVH6|C13orf42
     1  MFRKIHSIFN SSPQRKTAAE SPFYEGASPA VKLIRSSSMY VVGDHGEKFS ESLKKYKSTS
    61  SMDTSLYYLR QEEDRAWMYS RTQDCLQYLQ ELLALRKKYL SSFSDLKPHR TQGISSTSSK
   121  SSKGGKKTPV RSTPKEIKKA TPKKYSQFSA DVAEAIAFFD SIIAELDTER RPRAAEASLP
   181  NEDVDFDVAT SSREHSLHSN WILRAPRRHS EDIAAHTVHT VDGQFRRSTE HRTVGTQRRL
   241  ERHPIYLPKA VEGAFNTWKF KPKACKKDLG SSRQILFNFS GEDMEWDAEL FALEPQLSPG
   301  EDYYETENPK GQWLLRERLW ERTVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C13orf42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
0.6 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.6 nTPM
  • kidney: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • spleen: 0.1 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • early spermatids: 29 nCPM
  • late primary spermatocytes: 23 nCPM
  • undifferentiated spermatogonia: 16 nCPM
  • late spermatids: 13 nCPM
  • thymic myoid cells: 9.5 nCPM
  • oocytes: 9.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • choroid plexus: 0 nTPM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C13orf42 as an antibody target. Whether an autoantibody or antibody against C13orf42 could matter depends on whether native C13orf42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C13orf42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C13orf42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C13orf42. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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