Seroatlas · Human Serome Atlas

C12orf76

Uncharacterized protein C12orf76

Also known as: CL076_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N812
Gene
C12orf76
Canonical length
135 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for C12orf76 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

135 residues, UniProt reviewed canonical sequence.

>Q8N812|C12orf76
     1  MFQNLQGTFE KEIGKIIPFT IAFKRAEAVE PDGCVQSWRC CLPCDLGQAS RFIHTTVCSA
    61  IRWRSCKGER NFAERHILPA ELEEQSNHAG MGPILPAMPS VDGNHFQHPA GDCHPYGILC
   121  LQAHSASVTA RQVLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C12orf76 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 39 nTPM
  • choroid plexus: 18 nTPM
  • retina: 14 nTPM
  • epididymis: 8.8 nTPM
  • fallopian tube: 8.6 nTPM
  • thyroid gland: 7.9 nTPM

Single-cell type

  • platelets: 415 nCPM
  • oligodendrocytes: 92 nCPM
  • fallopian tube ciliated cells: 55 nCPM
  • respiratory ciliated cells: 53 nCPM
  • endometrial ciliated cells: 53 nCPM
  • late primary spermatocytes: 49 nCPM

Immune cell

  • basophil: 47 nTPM
  • memory B-cell: 15 nTPM
  • NK-cell: 15 nTPM
  • naive CD4 T-cell: 14 nTPM
  • memory CD4 T-cell: 10 nTPM
  • T-reg: 9.8 nTPM

Brain region

  • white matter: 65 nTPM
  • cerebellum: 48 nTPM
  • pons: 48 nTPM
  • cerebral cortex: 45 nTPM
  • medulla oblongata: 44 nTPM
  • hypothalamus: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.91
gnomAD pLI
0
gnomAD missense Z
0.44

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF5541
  • Family of unknown function (DUF5541)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C12orf76 as an antibody target. Whether an autoantibody or antibody against C12orf76 could matter depends on whether native C12orf76 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C12orf76 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C12orf76 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C12orf76. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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