C12orf71
Uncharacterized protein C12orf71
Also known as: CL071_HUMAN, LOC728858
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A8MTZ7
- Gene
- C12orf71
- Ensembl
- ENSG00000214700
- Chromosome
- 12
- Canonical length
- 269 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
No narrative summary is available for C12orf71 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
269 residues, UniProt reviewed canonical sequence.
>A8MTZ7|C12orf71
1 MAYSSSNSDI EDDSSKSNSN LSLSVGYFPC EDTPCEDTTS WEDAPSKGPS IHFLPPVQGA
61 WGTERIGRRM KRQDQIQDEP EQFCKLSIFL AWDVDIGSDN TDSRANRLLN GDNLWIDKLP
121 KERTKLSVGK LNNLVQEFQI FLENLKDDDA VFPETAQQDF QLSSGSPPEM VQMISQATAS
181 QRTSAPEISS ILSEQPEKDD TPSHTQAQCC LNFGWAFSWL RQRILPSLLR RDHPVNATKS
241 PHRSAPTKRL FHRGKRIQPQ ETLELGHPILocalizationUniProt · AlphaFold · HPA
Whether an antibody against C12orf71 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 2.9 nTPM
Expression across tissuesHPA
Tissue
- testis: 2.9 nTPM
- bone marrow: 1.3 nTPM
- skin: 0.7 nTPM
- cerebellum: 0.3 nTPM
- retina: 0.3 nTPM
- cerebral cortex: 0.2 nTPM
Single-cell type
- late primary spermatocytes: 27 nCPM
- early spermatids: 11 nCPM
- epididymal basal cells: 2.6 nCPM
- epicardial cells: 2.3 nCPM
- late spermatids: 2.3 nCPM
- cardiomyocytes: 0.5 nCPM
Immune cell
- NK-cell: 1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 2.6 nTPM
- amygdala: 2.3 nTPM
- hippocampal formation: 2.2 nTPM
- white matter: 2.2 nTPM
- thalamus: 2.1 nTPM
- pons: 1.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.72
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.36
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4640
- Domain of unknown function (DUF4640)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C12orf71 as an antibody target. Whether an autoantibody or antibody against C12orf71 could matter depends on whether native C12orf71 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C12orf71 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C12orf71 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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