Seroatlas · Human Serome Atlas

C12orf60

Uncharacterized protein C12orf60

Also known as: CL060_HUMAN, MGC47869

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5U649
Gene: C12orf60
Ensembl: ENSG00000182993
Chromosome: 12
Canonical length: 245 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

No narrative summary is available for C12orf60 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>Q5U649|C12orf60
     1  MSSESEKDKE RLIQAAKMFF FHVQDLASVI NTLTELFSRS MNTQILLMAV KNNSYIKDFF
    61  EQMLKIFKEM QSVVDARHDK IQKESLCSKV AMAMCSVVQK STNVEELHQS AKEVFKSAHT
   121  PVIISVLNSS NILGSLESSL SHLMKFPIMN LQLSDFYTED TKEQSDVTTS ERTRSPPGSS
   181  KTTMIDTLKK LQDVLKTEDS KNPTKSAADL LEQIVKAMGP ILEILQKAIK TMEMNISVFK
   241  KASDK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C12orf60 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
liver: 6.1 nTPM
retina: 5.9 nTPM
adrenal gland: 4.4 nTPM
heart muscle: 3.4 nTPM
spleen: 3.3 nTPM

Single-cell type

early spermatids: 577 nCPM
late primary spermatocytes: 293 nCPM
fibroblasts: 174 nCPM
late spermatids: 105 nCPM
fibro-adipogenic progenitors: 101 nCPM
vascular endothelial cells: 75 nCPM

Immune cell

naive CD4 T-cell: 1.8 nTPM
eosinophil: 1.7 nTPM
NK-cell: 1.7 nTPM
memory B-cell: 1.6 nTPM
T-reg: 1.6 nTPM
MAIT T-cell: 1.5 nTPM

Brain region

choroid plexus: 2.4 nTPM
white matter: 2.3 nTPM
medulla oblongata: 1.7 nTPM
spinal cord: 1.7 nTPM
pons: 1.6 nTPM
thalamus: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0.05
gnomAD missense Z: -0.01
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C12orf60 as an antibody target. Whether an autoantibody or antibody against C12orf60 could matter depends on whether native C12orf60 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C12orf60 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C12orf60 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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