Seroatlas · Human Serome Atlas

C12orf56

Uncharacterized protein C12orf56

Also known as: CL056_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXR9
Gene: C12orf56
Ensembl: ENSG00000185306
Chromosome: 12
Canonical length: 622 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C12orf56 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

622 residues, UniProt reviewed canonical sequence.

>Q8IXR9|C12orf56
     1  MASPLPSGFP ARRNSRLDVF LRRHLPPEVY DAVRAYEPCI VVSNSENHIL KYVVLSDRLV
    61  YLTENPPKSI RRVVALRDVV AIDLIDDYPE FLSSPDREIS QHIRIIYSST VLKKECKKSN
   121  SVRKFLFPFH HTKANNKKVK EEKNGLAFWR SKESRSLKES PLRDQQESST PSKDSTLCPR
   181  PGLKKLSLHG QGAFRPLPSP SRRSSQSAPT TGKAVSEPSC TTNTKEPQGL PDHNSISEIP
   241  FKCNGNGNEF YLGNSLLDSP SQSNSNLEKK ESELHLYVIS TTSSIFLHLK SSWNNYIIKA
   301  TLLQDPFYAS EFSPAIGSQK PYRSEEKIKH FSQLKSELFL KDNSLRRILS LLMELKVAAQ
   361  KNFILKRLFW KTSDLFYFIV NKLHEYLPES RDKNALQNQS QRVDELVACI EIIQTLVLMF
   421  RETETESSRL NTLAAKKGAL FNLLVILISE PQIPKSCPVF DIQLVADSAL VRMSFDAELQ
   481  KLILEYTNTA TALLYEILLV FQQGNLGLGS TKFAISWIMS FLQSCPPIIT FVASIVKQVV
   541  RGLSASFQLL SPCQAVLLYQ QFYILKSCLR HSRTLAEYIR NNYREEFRYF IHMPALQKRL
   601  PLCYPITQPT IQLFHEVLKL VE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C12orf56 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 7 nTPM

Expression across tissuesHPA

Tissue

testis: 7 nTPM
choroid plexus: 2.3 nTPM
thymus: 1.7 nTPM
vagina: 1.4 nTPM
retina: 1.3 nTPM
cervix: 1 nTPM

Single-cell type

choroid plexus epithelial cells: 170 nCPM
esophageal apical cells: 109 nCPM
müller glia: 84 nCPM
early spermatids: 64 nCPM
late primary spermatocytes: 58 nCPM
late spermatids: 58 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 15 nTPM
white matter: 4.6 nTPM
basal ganglia: 3 nTPM
medulla oblongata: 2.5 nTPM
thalamus: 2.5 nTPM
hypothalamus: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: 0.12
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4551
Protein of unknown function (DUF4551)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C12orf56 as an antibody target. Whether an autoantibody or antibody against C12orf56 could matter depends on whether native C12orf56 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C12orf56 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C12orf56 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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