C12orf54
Uncharacterized protein C12orf54
Also known as: CL054_HUMAN, MGC35033
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6X4T0
- Gene
- C12orf54
- Ensembl
- ENSG00000177627
- Chromosome
- 12
- Canonical length
- 127 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Intermediate filaments,Cytosol
OverviewNCBI Gene
No narrative summary is available for C12orf54 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
127 residues, UniProt reviewed canonical sequence.
>Q6X4T0|C12orf54
1 MAQHPCQDQE QKVEMTSKQQ RSTSIEETMR PQEKQVTITE TLWDQVLTVF KDIQKELQED
61 ARIRGMSNCS MTPMTSAPRT GSIRPPDSLM TPKLRRLQFS SGEQPSGGRI HNLKTQLFSQ
121 SAYYPGPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C12orf54 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 50 nTPM
Expression across tissuesHPA
Tissue
- testis: 50 nTPM
- tonsil: 0.6 nTPM
- esophagus: 0.5 nTPM
- cerebral cortex: 0.4 nTPM
- midbrain: 0.4 nTPM
- ovary: 0.4 nTPM
Single-cell type
- late spermatids: 4,343 nCPM
- early spermatids: 654 nCPM
- late primary spermatocytes: 111 nCPM
- esophageal basal cells: 31 nCPM
- esophageal suprabasal cells: 26 nCPM
- esophageal apical cells: 11 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 2.1 nTPM
- medulla oblongata: 1.5 nTPM
- pons: 1.5 nTPM
- white matter: 1.5 nTPM
- midbrain: 1.4 nTPM
- basal ganglia: 1.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.55
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.08
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4681
- Domain of unknown function (DUF4681)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C12orf54 as an antibody target. Whether an autoantibody or antibody against C12orf54 could matter depends on whether native C12orf54 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C12orf54 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C12orf54 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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