Seroatlas · Human Serome Atlas

C12orf50

Uncharacterized protein C12orf50

Also known as: CL050_HUMAN, FLJ35821

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NA57
Gene: C12orf50
Ensembl: ENSG00000165805
Chromosome: 12
Canonical length: 414 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in poly(A)+ mRNA export from nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

414 residues, UniProt reviewed canonical sequence.

>Q8NA57|C12orf50
     1  MEMQQNCSIS CFWETQPLGC VKISCIFYHS KPRNINGLFL PPSSNITLQK EIQEGIPLQS
    61  QSQEPLKPQE NISRPIHHPL VLKTNFEEEE EVDEQNDASS LWTKTPEEIE EKRAIKEMCY
   121  KSGEYYRFHT PPDILSSKSM TPTAEKQLEK PLENGSELQE GDSLTVPTKL SQYERQGEIK
   181  TSLHGKPKTD IAAFENGGGD CYVPQRVIFL GVDESEALTE EKEITISKCS NTKDNKDSPH
   241  PKHSLTTRLV PTTHVLNATE NISMKCREDP SSMNDVQPVK KPHFKGVKKR KWIYDEPQNF
   301  PNSGMQRAVQ APRPQNKMSY HRNNKNRNAE NASYIHVQRD AVRTVALNAP SRSRPTHGSY
   361  NKVHANREPK PNLSPDKYTS TSYNDSAWRK RIPFSKTYSK SEKIYPEPRR NGSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C12orf50 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

testis: 47 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 2,082 nCPM
early spermatids: 904 nCPM
late primary spermatocytes: 412 nCPM
sertoli cells: 6.5 nCPM
early primary spermatocytes: 5.4 nCPM
undifferentiated spermatogonia: 5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: -0.16
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

poly(A)+ mRNA export from nucleus

Protein domainsUniProt · Pfam · InterPro

Zinc-finger CCCH domain
Zinc-finger containing family
Protein of unknown function DUF5571
Family of unknown function (DUF5571)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C12orf50 as an antibody target. Whether an autoantibody or antibody against C12orf50 could matter depends on whether native C12orf50 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C12orf50 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C12orf50 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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