C12orf42
Uncharacterized protein C12orf42
Also known as: CL042_HUMAN, FLJ25323
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96LP6
- Gene
- C12orf42
- Ensembl
- ENSG00000179088
- Chromosome
- 12
- Canonical length
- 360 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for C12orf42 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
360 residues, UniProt reviewed canonical sequence.
>Q96LP6|C12orf42
1 MSTVICMKQR EEEFLLTIRP FANRMQKSPC YIPIVSSATL WDRSTPSAKH IPCYERTSVP
61 CSRFINHMKN FSESPKFRSL HFLNFPVFPE RTQNSMACKR LLHTCQYIVP RCSVSTVSFD
121 EESYEEFRSS PAPSSETDEA PLIFTARGET EERARGAPKQ AWNSSFLEQL VKKPNWAHSV
181 NPVHLEAQGI HISRHTRPKG QPLSSPKKNS GSAARPSTAI GLCRRSQTPG ALQSTGPSNT
241 ELEPEERMAV PAGAQAHPDD IQSRLLGASG NPVGKGAVAM APEMLPKHPH TPRDRRPQAD
301 TSLHGNLAGA PLPLLAGAST HFPSKRLIKV CSSAPPRPTR RFHTVCSQAL SRPVVNAHLHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C12orf42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.71
- Highest tissue expression
- 16 nTPM
Expression across tissuesHPA
Tissue
- testis: 16 nTPM
- thymus: 1.2 nTPM
- spleen: 1 nTPM
- lymph node: 0.8 nTPM
- tonsil: 0.7 nTPM
- appendix: 0.4 nTPM
Single-cell type
- late spermatids: 538 nCPM
- early spermatids: 507 nCPM
- late primary spermatocytes: 255 nCPM
- b-cells: 198 nCPM
- breast lactating cells: 120 nCPM
- microglia: 73 nCPM
Immune cell
- naive B-cell: 5.3 nTPM
- memory B-cell: 5.2 nTPM
- T-reg: 2.2 nTPM
- memory CD8 T-cell: 1.6 nTPM
- naive CD4 T-cell: 1.5 nTPM
- naive CD8 T-cell: 1.5 nTPM
Brain region
- cerebral cortex: 1.3 nTPM
- basal ganglia: 0.6 nTPM
- hippocampal formation: 0.6 nTPM
- white matter: 0.5 nTPM
- amygdala: 0.3 nTPM
- hypothalamus: 0.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.86
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.82
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4607
- Domain of unknown function (DUF4607)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C12orf42 as an antibody target. Whether an autoantibody or antibody against C12orf42 could matter depends on whether native C12orf42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C12orf42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C12orf42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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