Seroatlas · Human Serome Atlas

C11orf98

Uncharacterized protein C11orf98

Also known as: C11orf48, CK098_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
E9PRG8
Gene
C11orf98
Ensembl
ENSG00000278615
Chromosome
11
Canonical length
123 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene shares three exons in common with another gene, LBH domain containing 1 (GeneID:79081), but the encoded protein uses a reading frame that is different from that of the LBH domain containing 1 gene. [provided by RefSeq, Nov 2017]

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>E9PRG8|C11orf98
     1  MGAPGGKINR PRTELKKKLF KRRRVLNRER RLRHRVVGAV IDQGLITRHH LKKRASSARA
    61  NITLSGKKRR KLLQQIRLAQ KEKTAMEVEA PSKPARTSEP QLKRQKKTKA PQDVEMKDLE
   121  DES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C11orf98 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
95 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 95 nTPM
  • retina: 86 nTPM
  • kidney: 72 nTPM
  • liver: 70 nTPM
  • lymph node: 67 nTPM
  • spleen: 67 nTPM

Single-cell type

  • megakaryocytes: 12 nCPM
  • hepatocytes: 9.8 nCPM
  • parietal cells: 8.8 nCPM
  • endometrial secretory cells: 4.9 nCPM
  • oocytes: 4.6 nCPM
  • lacrimal acinar cells: 4.5 nCPM

Immune cell

  • eosinophil: 387 nTPM
  • memory B-cell: 347 nTPM
  • basophil: 341 nTPM
  • T-reg: 328 nTPM
  • naive B-cell: 311 nTPM
  • total PBMC: 284 nTPM

Brain region

  • cerebral cortex: 46 nTPM
  • pons: 43 nTPM
  • cerebellum: 41 nTPM
  • thalamus: 40 nTPM
  • white matter: 40 nTPM
  • medulla oblongata: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterized protein C11orf98
  • Family of unknown function (DUF5564)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C11orf98 as an antibody target. Whether an autoantibody or antibody against C11orf98 could matter depends on whether native C11orf98 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C11orf98 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C11orf98 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C11orf98. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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