Seroatlas · Human Serome Atlas

C11orf97

Uncharacterized protein C11orf97

Also known as: CK097_HUMAN, LINC01171

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVM6
Gene
C11orf97
Ensembl
ENSG00000257057
Chromosome
11
Canonical length
126 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in ciliary basal body. Predicted to be active in ciliary base. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>A0A1B0GVM6|C11orf97
     1  MTGEEAVVVT AVVAPKAGRE EEQPPPPAGL GCGARGEPGR GPLEHGQQWK KFLYCEPHKR
    61  IKEVLEEERH IKRDECHIKN PAAVALEGIW SIKRNLPVGG LKPGLPSRNS LLPQAKYYSR
   121  HGGLRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C11orf97 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • testis: 18 nTPM
  • fallopian tube: 18 nTPM
  • choroid plexus: 11 nTPM
  • basal ganglia: 10 nTPM
  • hippocampal formation: 4.8 nTPM
  • amygdala: 4.7 nTPM

Single-cell type

  • respiratory ciliated cells: 381 nCPM
  • epididymal efferent duct ciliated cells: 322 nCPM
  • fallopian tube ciliated cells: 320 nCPM
  • late primary spermatocytes: 269 nCPM
  • endometrial ciliated cells: 256 nCPM
  • early spermatids: 197 nCPM

Immune cell

  • eosinophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 9.5 nTPM
  • midbrain: 6.1 nTPM
  • basal ganglia: 6 nTPM
  • medulla oblongata: 5.3 nTPM
  • spinal cord: 4.7 nTPM
  • cerebral cortex: 3.8 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterised protein C11orf97-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C11orf97 as an antibody target. Whether an autoantibody or antibody against C11orf97 could matter depends on whether native C11orf97 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C11orf97 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C11orf97 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C11orf97. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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