Seroatlas · Human Serome Atlas

C11orf96

Uncharacterized protein C11orf96

Also known as: CK096_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z7L8
Gene
C11orf96
Canonical length
122 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C11orf96 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

122 residues, UniProt reviewed canonical sequence.

>Q7Z7L8|C11orf96
     1  MAAKPGELMG ICSSYQAVMP HFVCLADEFP QPVRPAKLPK GRGRLRRPRQ SRFKTQPVTF
    61  DEIQEVEEEG VSPMEEEKAK KSFLQSLECL RRSTQSLSLQ REQLSSCKLR NSLDSSDSDS
   121  AL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C11orf96 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
1,697 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 1,697 nTPM
  • fallopian tube: 765 nTPM
  • ovary: 712 nTPM
  • adipose tissue: 480 nTPM
  • lung: 388 nTPM
  • heart muscle: 276 nTPM

Single-cell type

  • vascular smooth muscle cells: 37 nCPM
  • smooth muscle cells: 18 nCPM
  • pericytes: 15 nCPM
  • fibroblasts: 5.8 nCPM
  • melanocytes: 4.7 nCPM
  • alveolar cells type 2: 4.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 178 nTPM
  • thalamus: 79 nTPM
  • hypothalamus: 75 nTPM
  • midbrain: 71 nTPM
  • pons: 65 nTPM
  • spinal cord: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0.01
gnomAD missense Z
0.78

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4695
  • Domain of unknown function (DUF4695)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C11orf96 as an antibody target. Whether an autoantibody or antibody against C11orf96 could matter depends on whether native C11orf96 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C11orf96 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C11orf96 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C11orf96. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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