Seroatlas · Human Serome Atlas

C11orf91

Uncharacterized protein C11orf91

Also known as: CK091_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3C1V1
Gene
C11orf91
Ensembl
ENSG00000205177
Chromosome
11
Canonical length
193 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

No narrative summary is available for C11orf91 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>Q3C1V1|C11orf91
     1  MPKGRRGSHS PTMSQRSAPP LYFPSLYDRG ISSSPLSDFN IWKKLFVPLK AGGAPVGGAA
    61  GARSLSQALP APAPPPPPPP GLGPSSERPW PSPWPSGLAS IPYEPLRFFY SPPPGPEVVA
   121  SPLVPCPSTP RLASASHPEE LCELEIRIKE LELLTITGDG FDSQSYTFLK ALKDEKLQGL
   181  KTKQPGKKSA SLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C11orf91 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 9 nTPM
  • adipose tissue: 4.4 nTPM
  • gallbladder: 4.3 nTPM
  • esophagus: 2.8 nTPM
  • stomach: 1.9 nTPM
  • breast: 1.4 nTPM

Single-cell type

  • late primary spermatocytes: 26 nCPM
  • early spermatids: 10 nCPM
  • late spermatids: 3.1 nCPM
  • early primary spermatocytes: 3 nCPM
  • breast secretory cells: 0.9 nCPM
  • esophageal apical cells: 0.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 5.9 nTPM
  • cerebellum: 4.1 nTPM
  • pons: 2.8 nTPM
  • white matter: 2.7 nTPM
  • hypothalamus: 2.6 nTPM
  • midbrain: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.76
gnomAD pLI
0.01
gnomAD missense Z
0.51
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterized protein C11orf91-like
  • Family of unknown function (DUF5529)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C11orf91 as an antibody target. Whether an autoantibody or antibody against C11orf91 could matter depends on whether native C11orf91 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C11orf91 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C11orf91 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C11orf91. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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