Seroatlas · Human Serome Atlas

C11orf87

Uncharacterized protein C11orf87

Also known as: CK087_HUMAN, LOC399947, LOH11CR1A, NEURIM1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NUJ2
Gene
C11orf87
Ensembl
ENSG00000185742
Chromosome
11
Canonical length
197 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q6NUJ2|C11orf87
     1  MSARAPKELR LALPPCLLNR TFASPNASGS GNTGARGPGA VGSGTCITQV GQQLFQSFSS
    61  TLVLIVLVTL IFCLIVLSLS TFHIHKRRMK KRKMQRAQEE YERDHCSGSR GGGGLPRPGR
   121  QAPTHAKETR LERQPRDSPF CAPSNASSLS SSSPGLPCQG PCAPPPPPPA SSPQGAHAAS
   181  SCLDTAGEGL LQTVVLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C11orf87 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 18 nTPM
  • basal ganglia: 7.2 nTPM
  • hippocampal formation: 7.1 nTPM
  • amygdala: 4.6 nTPM
  • hypothalamus: 2.9 nTPM
  • cerebellum: 2.2 nTPM

Single-cell type

  • brain inhibitory neurons: 48 nCPM
  • brain excitatory neurons: 47 nCPM
  • retinal amacrine cells: 21 nCPM
  • other brain neurons: 18 nCPM
  • retinal horizontal cells: 14 nCPM
  • epicardial cells: 6.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 83 nTPM
  • hippocampal formation: 58 nTPM
  • thalamus: 50 nTPM
  • basal ganglia: 46 nTPM
  • white matter: 42 nTPM
  • amygdala: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.24
gnomAD pLI
0.28
gnomAD missense Z
0.15
DepMap mean gene effect
0.19
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterized protein C11orf87

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C11orf87 as an antibody target. Whether an autoantibody or antibody against C11orf87 could matter depends on whether native C11orf87 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C11orf87 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C11orf87 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C11orf87. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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