Seroatlas · Human Serome Atlas

C11orf86

Uncharacterized protein C11orf86

Also known as: CK086_HUMAN, FLJ22675

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NJI1
Gene
C11orf86
Ensembl
ENSG00000173237
Chromosome
11
Canonical length
115 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C11orf86 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>A6NJI1|C11orf86
     1  MGTGLRSQSL REPRPSYGKL QEPWGRPQEG QLRRALSLRQ GQEKSRSQGL ERGTEGPDAT
    61  AQERVPGSLG DTEQLIQAQR RGSRWWLRRY QQVRRRWESF VAIFPSVTLS QPASP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C11orf86 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 65 nTPM
  • small intestine: 61 nTPM
  • colon: 9.9 nTPM
  • rectum: 6.2 nTPM
  • adrenal gland: 5.3 nTPM
  • stomach: 2 nTPM

Single-cell type

  • enterocytes: 499 nCPM
  • colonocytes: 190 nCPM
  • foveolar cells: 39 nCPM
  • tuft cells: 12 nCPM
  • gastric progenitor cells: 7.7 nCPM
  • goblet cells: 7.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 0.8 nTPM
  • medulla oblongata: 0.2 nTPM
  • spinal cord: 0.2 nTPM
  • white matter: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.9
gnomAD pLI
0
gnomAD missense Z
0.7
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4633
  • Domain of unknown function (DUF4633)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C11orf86 as an antibody target. Whether an autoantibody or antibody against C11orf86 could matter depends on whether native C11orf86 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C11orf86 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C11orf86 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C11orf86. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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