Seroatlas · Human Serome Atlas

C11orf71

Uncharacterized protein C11orf71

Also known as: CK071_HUMAN, FLJ20010

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6IPW1
Gene
C11orf71
Ensembl
ENSG00000180425
Chromosome
11
Canonical length
123 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

No narrative summary is available for C11orf71 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>Q6IPW1|C11orf71
     1  MALNNVSLSS GDQRSRVAYR SSHGDLRPRA SALAMVSGDG FLVSRPEAIH LGPRQAVRPS
    61  VRAESRRVDG GGRSPREPDG RGRSRQARFS PYPIPAVEPD LLRSVLQQRL IALGGVIAAR
   121  ISV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C11orf71 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
131 nTPM

Expression across tissuesHPA

Tissue

  • testis: 131 nTPM
  • epididymis: 21 nTPM
  • liver: 21 nTPM
  • retina: 15 nTPM
  • tongue: 14 nTPM
  • skeletal muscle: 14 nTPM

Single-cell type

  • late spermatids: 9,404 nCPM
  • early spermatids: 1,626 nCPM
  • late primary spermatocytes: 751 nCPM
  • epididymal principal cells: 124 nCPM
  • parietal cells: 57 nCPM
  • hepatocytes: 56 nCPM

Immune cell

  • basophil: 16 nTPM
  • classical monocyte: 16 nTPM
  • neutrophil: 12 nTPM
  • NK-cell: 12 nTPM
  • plasmacytoid DC: 12 nTPM
  • non-classical monocyte: 12 nTPM

Brain region

  • midbrain: 22 nTPM
  • white matter: 20 nTPM
  • medulla oblongata: 16 nTPM
  • hypothalamus: 15 nTPM
  • basal ganglia: 15 nTPM
  • pons: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.5
gnomAD pLI
0.21
gnomAD missense Z
-0.29
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4687
  • Domain of unknown function (DUF4687)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C11orf71 as an antibody target. Whether an autoantibody or antibody against C11orf71 could matter depends on whether native C11orf71 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C11orf71 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C11orf71 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C11orf71. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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