Seroatlas · Human Serome Atlas

C11orf68

UPF0696 protein C11orf68

Also known as: BLES03, CK068_HUMAN, P5326

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H3H3
Gene: C11orf68
Ensembl: ENSG00000175573
Chromosome: 11
Canonical length: 292 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q9H3H3|C11orf68
     1  MAAAAAAAVA GVGRGGGGAE PRQERSRARG WAGVERSEGR RMEPGEELEE EGSPGGREDG
    61  FTAEHLAAEA MAADMDPWLV FDARTTPATE LDAWLAKYPP SQVTRYGDPG SPNSEPVGWI
   121  AVYGQGYSPN SGDVQGLQAA WEALQTSGRP ITPGTLRQLA ITHHVLSGKW LMHLAPGFKL
   181  DHAWAGIARA VVEGQLQVAK VSPRAKEGGR QVICVYTDDF TDRLGVLEAD SAIRAAGIKC
   241  LLTYKPDVYT YLGIYRANRW HLCPTLYESR FQLGGSARGS RVLDRANNVE LT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C11orf68 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 91 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 91 nTPM
skeletal muscle: 78 nTPM
cerebral cortex: 72 nTPM
blood vessel: 62 nTPM
endometrium: 52 nTPM
testis: 52 nTPM

Single-cell type

late spermatids: 41 nCPM
platelets: 40 nCPM
esophageal apical cells: 38 nCPM
epididymal principal cells: 36 nCPM
peritubular myoid cells: 32 nCPM
breast myoepithelial cells: 31 nCPM

Immune cell

neutrophil: 9.1 nTPM
basophil: 6.8 nTPM
naive B-cell: 5.4 nTPM
gdT-cell: 5.3 nTPM
naive CD8 T-cell: 5.3 nTPM
naive CD4 T-cell: 5.2 nTPM

Brain region

cerebral cortex: 69 nTPM
cerebellum: 64 nTPM
white matter: 55 nTPM
basal ganglia: 54 nTPM
medulla oblongata: 53 nTPM
thalamus: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0.25
gnomAD missense Z: 1.33
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Protein domainsUniProt · Pfam · InterPro

Translation Initiation factor eIF- 4e-like
Basophilic leukemia-expressed protein Bles03-like
Basophilic leukemia-expressed protein Bles03

KeywordsUniProt

Methylation

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C11orf68 as an antibody target. Whether an autoantibody or antibody against C11orf68 could matter depends on whether native C11orf68 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C11orf68 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C11orf68 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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