C11orf54
Ester hydrolase C11orf54
Also known as: CK054_HUMAN, PTD012
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H0W9
- Gene
- C11orf54
- Ensembl
- ENSG00000182919
- Chromosome
- 11
- Canonical length
- 315 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nuclear bodies
OverviewNCBI Gene
Enables hydrolase activity, acting on ester bonds and zinc ion binding activity. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
315 residues, UniProt reviewed canonical sequence.
>Q9H0W9|C11orf54
1 MACAEFSFHV PSLEELAGVM QKGLKDNFAD VQVSVVDCPD LTKEPFTFPV KGICGKTRIA
61 EVGGVPYLLP LVNQKKVYDL NKIAKEIKLP GAFILGAGAG PFQTLGFNSE FMPVIQTESE
121 HKPPVNGSYF AHVNPADGGC LLEKYSEKCH DFQCALLANL FASEGQPGKV IEVKAKRRTG
181 PLNFVTCMRE TLEKHYGNKP IGMGGTFIIQ KGKVKSHIMP AEFSSCPLNS DEEVNKWLHF
241 YEMKAPLVCL PVFVSRDPGF DLRLEHTHFF SRHGEGGHYH YDTTPDIVEY LGYFLPAEFL
301 YRIDQPKETH SIGRDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C11orf54 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.2
- Highest tissue expression
- 530 nTPM
Expression across tissuesHPA
Tissue
- kidney: 530 nTPM
- liver: 242 nTPM
- tongue: 51 nTPM
- duodenum: 50 nTPM
- pancreas: 49 nTPM
- small intestine: 48 nTPM
Single-cell type
- hepatocytes: 109 nCPM
- choroid plexus epithelial cells: 60 nCPM
- oligodendrocyte progenitor cells: 54 nCPM
- astrocytes: 50 nCPM
- bergmann glia: 47 nCPM
- oligodendrocytes: 47 nCPM
Immune cell
- neutrophil: 102 nTPM
- basophil: 75 nTPM
- eosinophil: 74 nTPM
- plasmacytoid DC: 32 nTPM
- T-reg: 32 nTPM
- classical monocyte: 30 nTPM
Brain region
- white matter: 65 nTPM
- medulla oblongata: 54 nTPM
- choroid plexus: 53 nTPM
- basal ganglia: 49 nTPM
- cerebellum: 47 nTPM
- hypothalamus: 46 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.52
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.21
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- selective
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Ester hydrolase C11orf54, Domain of unknown function DUF1907
- Domain of Unknown Function (DUF1907)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of C11orf54 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C11orf54 as an antibody target. Whether an autoantibody or antibody against C11orf54 could matter depends on whether native C11orf54 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C11orf54 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C11orf54 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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