Seroatlas · Human Serome Atlas

C11orf52

Uncharacterized protein C11orf52

Also known as: CK052_HUMAN, FLJ25219, MGC14839

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96A22
Gene
C11orf52
Ensembl
ENSG00000149300
Chromosome
11
Canonical length
123 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cell Junctions

OverviewNCBI Gene

Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>Q96A22|C11orf52
     1  MGNRVCCGGS WSCPSTFQKK KKTGSQTRRT LKPQPQQLQQ NLPKGHETTG HTYERVLQQQ
    61  GSQERSPGLM SEDSNLHYAD IQVCSRPHAR EVKHVHLENA TEYATLRFPQ ATPRYDSKNG
   121  TLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C11orf52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 41 nTPM
  • parathyroid gland: 29 nTPM
  • pancreas: 26 nTPM
  • salivary gland: 25 nTPM
  • breast: 24 nTPM
  • epididymis: 22 nTPM

Single-cell type

  • choroid plexus epithelial cells: 5 nCPM
  • brain excitatory neurons: 1.8 nCPM
  • ependymal cells: 1.7 nCPM
  • astrocytes: 1.5 nCPM
  • oligodendrocytes: 1 nCPM
  • bergmann glia: 0.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 7.6 nTPM
  • choroid plexus: 3.8 nTPM
  • pons: 2.6 nTPM
  • white matter: 2.1 nTPM
  • cerebral cortex: 1.7 nTPM
  • medulla oblongata: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.69
gnomAD pLI
0
gnomAD missense Z
0.79
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4578
  • Domain of unknown function (DUF4578)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C11orf52 as an antibody target. Whether an autoantibody or antibody against C11orf52 could matter depends on whether native C11orf52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C11orf52 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C11orf52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C11orf52. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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