Seroatlas · Human Serome Atlas

C11orf42

Uncharacterized protein C11orf42

Also known as: CK042_HUMAN, MGC34805

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5U0
Gene: C11orf42
Ensembl: ENSG00000180878
Chromosome: 11
Canonical length: 333 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Vesicles,Plasma membrane

OverviewNCBI Gene

Located in sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>Q8N5U0|C11orf42
     1  MLVGTPNLLT LDEADATWTL IKDKVIEEHF GPNAVAVPFL SDAACYDLLG VLVKQSRPAH
    61  TRLALPGRQG RRALKPVGPL PSLLEQAGSE GAFAHCTREY SPNGRAERAY EETRMLDGQP
   121  CKIRLHMGDL RKKVAFLLLP PGQVSLQQTL PWLRSTHSIY VIYQVFSCSW LQLGLTSTAR
   181  EPQLLRLLRS LPVAFSCLKF SLQSKGVLGP QKPLTKDPLP HGANWVRPNL SIMPPLAPTS
   241  APADTTEAAD VPPPVPAPPT PPPQEGPEDK PTRFSYKGRN PFWRGPQILS ENWLFSPRSP
   301  PPGAQGGGPR DPDGHSMSLP LLQGLSSEFD SDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C11orf42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
skin: 1.5 nTPM
retina: 1.3 nTPM
cerebellum: 0.9 nTPM
duodenum: 0.9 nTPM
cerebral cortex: 0.8 nTPM

Single-cell type

late spermatids: 1,337 nCPM
early spermatids: 219 nCPM
late primary spermatocytes: 12 nCPM
sertoli cells: 4.5 nCPM
rod photoreceptor cells: 4.3 nCPM
retinal amacrine cells: 4.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 8.2 nTPM
cerebral cortex: 6.6 nTPM
basal ganglia: 6.2 nTPM
white matter: 5.9 nTPM
hippocampal formation: 5.6 nTPM
hypothalamus: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: -0.05
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

sperm flagellum

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4663
Domain of unknown function (DUF4663)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C11orf42 as an antibody target. Whether an autoantibody or antibody against C11orf42 could matter depends on whether native C11orf42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C11orf42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C11orf42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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