Seroatlas · Human Serome Atlas

C11orf40

Putative uncharacterized protein C11orf40

Also known as: CK040_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WZ69
Gene: C11orf40
Canonical length: 217 aa

OverviewNCBI Gene

No narrative summary is available for C11orf40 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>Q8WZ69|C11orf40
     1  MALVQALVPR EREPKLSILQ MDRGDPQHSS HWCPEREKVK LLTLKPRETS KNILINFYRA
    61  FNLDKDVFIH QANHPLTVPS SVVMGDNGHT LAEDDKRPCF RVLPCYLERV SSGISISWIS
   121  APLPVGAMKH QLLCDLMDLI TLSFWLAGQC MSLKATNMQH CKCSIATSDW AIELDRTDYK
   181  TLPSEYSILA LLQVFAGKNC MDRVLLHVDV NYLKSLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C11orf40 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: -2.86

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF5552
Family of unknown function (DUF5552)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C11orf40 as an antibody target. Whether an autoantibody or antibody against C11orf40 could matter depends on whether native C11orf40 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C11orf40 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C11orf40 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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