Seroatlas · Human Serome Atlas

C11orf24

Uncharacterized protein C11orf24

Also known as: CK024_HUMAN, DM4E3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96F05
Gene: C11orf24
Ensembl: ENSG00000171067
Chromosome: 11
Canonical length: 449 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

449 residues, UniProt reviewed canonical sequence.

>Q96F05|C11orf24
     1  MWTALVLIWI FSLSLSESHA ASNDPRNFVP NKMWKGLVKR NASVETVDNK TSEDVTMAAA
    61  SPVTLTKGTS AAHLNSMEVT TEDTSRTDVS EPATSGGAAD GVTSIAPTAV ASSTTAASIT
   121  TAASSMTVAS SAPTTAASST TVASIAPTTA ASSMTAASST PMTLALPAPT STSTGRTPST
   181  TATGHPSLST ALAQVPKSSA LPRTATLATL ATRAQTVATT ANTSSPMSTR PSPSKHMPSD
   241  TAASPVPPMR PQAQGPISQV SVDQPVVNTT NKSTPMPSNT TPEPAPTPTV VTTTKAQARE
   301  PTASPVPVPH TSPIPEMEAM SPTTQPSPMP YTQRAAGPGT SQAPEQVETE ATPGTDSTGP
   361  TPRSSGGTKM PATDSCQPST QGQYMVVTTE PLTQAVVDKT LLLVVLLLGV TLFITVLVLF
   421  ALQAYESYKK KDYTQVDYLI NGMYADSEM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C11orf24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 83 nTPM

Expression across tissuesHPA

Tissue

liver: 83 nTPM
small intestine: 56 nTPM
duodenum: 51 nTPM
blood vessel: 47 nTPM
endometrium: 35 nTPM
salivary gland: 33 nTPM

Single-cell type

enterocytes: 183 nCPM
hepatocytes: 141 nCPM
plasma cells: 75 nCPM
goblet cells: 63 nCPM
melanocytes: 41 nCPM
extravillous trophoblasts: 40 nCPM

Immune cell

naive B-cell: 36 nTPM
memory B-cell: 27 nTPM
plasmacytoid DC: 27 nTPM
myeloid DC: 20 nTPM
intermediate monocyte: 19 nTPM
basophil: 17 nTPM

Brain region

white matter: 26 nTPM
medulla oblongata: 26 nTPM
thalamus: 22 nTPM
pons: 22 nTPM
cerebellum: 21 nTPM
basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: -0.41
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF5585
Erythrocyte Invasion and Immune Modulation Protein
Family of unknown function (DUF5585)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C11orf24 as an antibody target. Whether an autoantibody or antibody against C11orf24 could matter depends on whether native C11orf24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C11orf24 is annotated at the cell surface, where native C11orf24 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label C11orf24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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