Seroatlas · Human Serome Atlas

C11orf16

Uncharacterized protein C11orf16

Also known as: CK016_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQ32
Gene: C11orf16
Ensembl: ENSG00000176029
Chromosome: 11
Canonical length: 467 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Vesicles

OverviewNCBI Gene

No narrative summary is available for C11orf16 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

467 residues, UniProt reviewed canonical sequence.

>Q9NQ32|C11orf16
     1  MESSTGPRMP LLKYCSVATS LKAPGWDGAA PPWDLSFTYP FALQAPWLTG HKPLARHASS
    61  CPCLHVADPA WQGPGWLGRA GDAANTWVLA RREADGFYYR AQIKATPELE RQGVLLVEFE
   121  APLVAGPKLP AQQQRVVLEE DVIPLSPSVG YSLRPGDKVL ALWEPGQQQY GPGTVLLGLE
   181  MRDPQRASKE KEITVHFWNG KAAKVPLGGV QSVSLTIWKK AVERLHKSFT REHPRPLHWA
   241  PCCSLLGPIT GRITNELPPD APFLCPLCHH HACCQLLCQG CLCGCPPCGT TWWPLTRTSE
   301  VMARELPELE PTAQLLPLEG PKEEKVAMHA PLAVSSSSSS SCEQDGVEND LEMGPPQRLM
   361  VNSAVNTDPI FLEMPLRQSG LCQPEWRYWK RNGPEPCLGK PGTRYSNICK EEKDHKQQRA
   421  QTAVVGTTKE LVSKATHMKP PRTPPGEAEH RKRSQSLAIC QWNKNSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C11orf16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 13 nTPM
fallopian tube: 12 nTPM
thymus: 5.8 nTPM
lung: 2.6 nTPM
testis: 2.1 nTPM
pituitary gland: 1 nTPM

Single-cell type

respiratory ciliated cells: 240 nCPM
respiratory ionocytes: 236 nCPM
fallopian tube ciliated cells: 94 nCPM
salivary ionocytes: 92 nCPM
ependymal cells: 66 nCPM
endometrial ciliated cells: 65 nCPM

Immune cell

T-reg: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 14 nTPM
midbrain: 5.2 nTPM
medulla oblongata: 3.2 nTPM
spinal cord: 2.7 nTPM
pons: 2.1 nTPM
hypothalamus: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: -0.38
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C11orf16 as an antibody target. Whether an autoantibody or antibody against C11orf16 could matter depends on whether native C11orf16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C11orf16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C11orf16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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