Seroatlas · Human Serome Atlas

C10orf95

Uncharacterized protein C10orf95

Also known as: CJ095_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7T3
Gene: C10orf95
Canonical length: 257 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C10orf95 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>Q9H7T3|C10orf95
     1  MERSNAATKC GEEPRSGSRR LPKAEGDKSG SAGAPSKNSS RLGGRPCMCT AGRRPNRASG
    61  RRRRSCSPAP TWPPLCCYPQ SRPTASAAGP GACMRASGRP HGNTTASTAP PRHPRPRRPG
   121  GPALRPTPRP CAGPAPPPAS RDCRCRRPRR WPRAGRRGRR AGACKPSCAG AAWSARGAPL
   181  CSYRTSCAGS CGARTAPTPA PTCASPSAAA SSCCRRRRAC SSPTTAWSGA CGAGPTAATA
   241  AQPGKPRSAA APGRARA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C10orf95 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.76
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 9.1 nTPM
thyroid gland: 4.9 nTPM
pancreas: 4.4 nTPM
retina: 4.4 nTPM
salivary gland: 3.8 nTPM
skin: 3.8 nTPM

Single-cell type

respiratory ciliated cells: 83 nCPM
fallopian tube ciliated cells: 72 nCPM
epididymal efferent duct ciliated cells: 54 nCPM
syncytiotrophoblasts: 52 nCPM
oocytes: 46 nCPM
tuft cells: 46 nCPM

Immune cell

naive CD4 T-cell: 12 nTPM
memory B-cell: 11 nTPM
NK-cell: 10 nTPM
naive CD8 T-cell: 9.9 nTPM
T-reg: 9.6 nTPM
memory CD4 T-cell: 8.4 nTPM

Brain region

cerebellum: 11 nTPM
cerebral cortex: 7.4 nTPM
choroid plexus: 7.3 nTPM
hypothalamus: 7.2 nTPM
amygdala: 6.6 nTPM
basal ganglia: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C10orf95 as an antibody target. Whether an autoantibody or antibody against C10orf95 could matter depends on whether native C10orf95 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C10orf95 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C10orf95 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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