Seroatlas · Human Serome Atlas

C10orf90

(E2-independent) E3 ubiquitin-conjugating enzyme FATS

Also known as: bA422P15.2, CJ090_HUMAN, FATS, FLJ32938

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96M02
Gene: C10orf90
Ensembl: ENSG00000154493
Chromosome: 10
Canonical length: 699 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable histone deacetylase binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein stabilization; regulation of cell cycle process; and response to ionizing radiation. Located in cytoskeleton; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

699 residues, UniProt reviewed canonical sequence.

>Q96M02|C10orf90
     1  MLKLSGEGLR DSYHSRRDQI ALKNLQSDVT EAKSDFTKET LASQNTKMIS SIVISQMIDE
    61  NKSRENRASL PLPCAIAQSR AHHAKQSLAN RSGVNIHRAF ALLPGRLGIP APSDERGPEA
   121  ELPPKEERPC GGPRRGFASI TITARRVGPP ARALVWGTAG DSLCPKCRAE DTLFQAPPAL
   181  ANGAHPGRHQ RSFACTEFSR NSSVVRLKVP EAHTGLCERR KYWVTHADDK ETSFSPDTPL
   241  SGKSPLVFSS CVHLRVSQQC PDSIYYVDKS LSVPIEPPQI ASPKMHRSVL SLNLNCSSHR
   301  LTADGVDGLV NREPISEALK QELLEGDQDL VGQRWNPGLQ ESHLKETPSL RRVHLGTGAC
   361  PWSGSFPLEN TELANVGANQ VTVRKGEKDH TTHCHASDHA NQLSIHIPGW SYRAVHTKVF
   421  SGSSKRQQGE VCMTVSAPPV EQKPTRHFLP IGDSSPSDDC LSRDLSEPTE RRHQSFLKPR
   481  ILFPGFLCPL QDVCASLQED NGVQIESKFP KGDYTCCDLV VKIKECKKSE DPTTPEPSPA
   541  APSPAPRDGA GSPGLSEDCS ESQQTPARSL TLQEALEVRK PQFISRSQER LKKLEHMVQQ
   601  RKAQRKEDLR QKQSLLPIRT SKKQFTIPHP LSDNLFKPKE RCISEKEMHM RSKRIYDNLP
   661  EVKKKKEEQR KRVILQSNRL RAEVFKKQLL DQLLQRNAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C10orf90 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 19 nTPM
midbrain: 13 nTPM
hippocampal formation: 10 nTPM
basal ganglia: 8.2 nTPM
amygdala: 6.7 nTPM
testis: 5.8 nTPM

Single-cell type

oligodendrocytes: 1,102 nCPM
oligodendrocyte progenitor cells: 330 nCPM
late spermatids: 257 nCPM
early spermatids: 227 nCPM
salivary acinar cells: 126 nCPM
melanocytes: 111 nCPM

Immune cell

MAIT T-cell: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 111 nTPM
basal ganglia: 81 nTPM
thalamus: 75 nTPM
medulla oblongata: 71 nTPM
cerebral cortex: 65 nTPM
midbrain: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: -0.45
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin protein ligase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

ALMS motif
ALMS motif
Centrosomal protein C10orf90, N-terminal
Centrosomal C10orf90

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C10orf90 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HDAC1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C10orf90 as an antibody target. Whether an autoantibody or antibody against C10orf90 could matter depends on whether native C10orf90 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C10orf90 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C10orf90 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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