Seroatlas · Human Serome Atlas

C10orf67

Uncharacterized protein C10orf67, mitochondrial

Also known as: bA215C7.4, C10orf115, CJ067_HUMAN, LINC01552, MGC46732

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IYJ2
Gene
C10orf67
Ensembl
ENSG00000179133
Chromosome
10
Canonical length
551 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Microtubules,Mitochondria

OverviewNCBI Gene

Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

551 residues, UniProt reviewed canonical sequence.

>Q8IYJ2|C10orf67
     1  MMALVRDRRA HYVMSIVIRW VHCFSSSLRG TFGTRWEAMK AKATELRVCC ARRKREAREF
    61  KPPQMRGSTR LNISDDLKIG FFSTDHATQT DSSEILSVKE LSSSTQKLAQ MMKSLQVDFG
   121  FLKQLLQLKF EDRLKEESLS LFTILHDRIL EIEKHYQQNE DKMRKSFNQQ LADAIAVIKG
   181  MYQQFFEVEE ENVSLQDAST VKTNILLRKL KEKEEVIKEL KEELDQYKDF GFHKMESFAK
   241  ETSSPKSNLE KENLEYKVEN ERLLQIISEL EEEIQINLKE NSGLEDELIS MKEMAEKDHK
   301  TIQKLMDSRD RLREELHYEK SLVQDVINKQ KEDKEMRKKY GSLSVKVARS AKGREASLSP
   361  WPKSPPSTTA LRPHSATMSV SSAGAQKAKM PKKALKEDQA VVEDKHGLES QIEALKANLE
   421  NEKKKVERFR KEADRLNKSW EKRFFILRNS FHVLKNEMFT RHTLFRQFAV LADTSFNYIK
   481  VKPLLVQSRT TMTAISSSSH CTSSIDGKHV DVVSDQAALQ LSPKGKLSES PKEESLEEPS
   541  MRQSSPAETV D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C10orf67 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • testis: 12 nTPM
  • choroid plexus: 5.4 nTPM
  • fallopian tube: 4.6 nTPM
  • kidney: 3.3 nTPM
  • lung: 2.7 nTPM
  • pituitary gland: 1.6 nTPM

Single-cell type

  • respiratory ciliated cells: 166 nCPM
  • late primary spermatocytes: 124 nCPM
  • ependymal cells: 110 nCPM
  • early primary spermatocytes: 98 nCPM
  • fallopian tube ciliated cells: 93 nCPM
  • epididymal efferent duct ciliated cells: 93 nCPM

Immune cell

  • T-reg: 1.2 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • naive B-cell: 0.3 nTPM
  • memory B-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM

Brain region

  • choroid plexus: 15 nTPM
  • midbrain: 8.5 nTPM
  • medulla oblongata: 8.3 nTPM
  • hypothalamus: 7.7 nTPM
  • white matter: 7.7 nTPM
  • hippocampal formation: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.8
gnomAD pLI
0
gnomAD missense Z
0.27
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Domain of unknown function DUF4709
  • Domain of unknown function DUF4724
  • Uncharacterized protein C10orf67-like
  • Domain of unknown function (DUF4709)
  • Domain of unknown function (DUF4724)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C10orf67 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C10orf67 as an antibody target. Whether an autoantibody or antibody against C10orf67 could matter depends on whether native C10orf67 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C10orf67 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C10orf67 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C10orf67. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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