C10orf55
Uncharacterized protein C10orf55
Also known as: CJ055_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for C10orf55 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
151 residues, UniProt reviewed canonical sequence.
>Q5SWW7|C10orf55
1 MFLHLDSHSS LERTKPTVVG VDTHMELDEV HCCPGRDSGG GFIKGPMLQG LQGEGKLAPI
61 PKPTLPSPSR LTLFVSSSQM EDHGFPARRN GLTQASFIYQ MPAGWGSPGG LFLPCQPVPT
121 PVVLKPPLPP CPISWGESGP AVDGIRRTPA PLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C10orf55 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.94
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.42
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C10orf55 as an antibody target. Whether an autoantibody or antibody against C10orf55 could matter depends on whether native C10orf55 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C10orf55 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C10orf55 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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