Seroatlas · Human Serome Atlas

C10orf53

UPF0728 protein C10orf53

Also known as: CJ053_HUMAN, Em:AC069546.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N6V4
Gene
C10orf53
Ensembl
ENSG00000178645
Chromosome
10
Canonical length
93 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C10orf53 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

93 residues, UniProt reviewed canonical sequence.

>Q8N6V4|C10orf53
     1  MPKNAVVILR YGPYSAAGLP VEHHTFRLQG LQAVLAIDGH EVILEKIEDW NVVELMVNEE
    61  VIFHCNIKDL EFGGDGKLDP LCEKARIAVL NAY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C10orf53 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • testis: 11 nTPM
  • bone marrow: 0.3 nTPM
  • fallopian tube: 0.3 nTPM
  • skin: 0.3 nTPM
  • hypothalamus: 0.2 nTPM
  • retina: 0.2 nTPM

Single-cell type

  • late spermatids: 2,419 nCPM
  • early spermatids: 477 nCPM
  • late primary spermatocytes: 416 nCPM
  • early primary spermatocytes: 17 nCPM
  • ependymal cells: 11 nCPM
  • sertoli cells: 6.5 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebellum: 7 nTPM
  • medulla oblongata: 5 nTPM
  • cerebral cortex: 4.9 nTPM
  • midbrain: 4.6 nTPM
  • white matter: 4.4 nTPM
  • pons: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.07
gnomAD pLI
0.58
gnomAD missense Z
0.46
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterised protein family UPF0728
  • Uncharacterised protein family UPF0728

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C10orf53 as an antibody target. Whether an autoantibody or antibody against C10orf53 could matter depends on whether native C10orf53 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C10orf53 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C10orf53 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C10orf53. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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