Seroatlas · Human Serome Atlas

C10orf143

Uncharacterized protein C10orf143

Also known as: CJ143_HUMAN, LINC00959

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GUT2
Gene
C10orf143
Ensembl
ENSG00000237489
Chromosome
10
Canonical length
108 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C10orf143 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>A0A1B0GUT2|C10orf143
     1  MDSLALGRWR QRRAEDLQVP GDVKRVCRRL EASGHERGCH QVNACALASW GPEDRELPSR
    61  GCLPAPRPES GQGRLSTGIS QNGGRSSAQP CPRCIAGESG HFSHTKNH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C10orf143 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
9 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 9 nTPM
  • colon: 6.4 nTPM
  • seminal vesicle: 6.2 nTPM
  • urinary bladder: 6.2 nTPM
  • kidney: 6.1 nTPM
  • epididymis: 5.4 nTPM

Single-cell type

  • bergmann glia: 26 nCPM
  • myonuclei: 26 nCPM
  • ependymal cells: 25 nCPM
  • pituitary stem cells: 25 nCPM
  • astrocytes: 25 nCPM
  • corticotrophs: 22 nCPM

Immune cell

  • naive CD8 T-cell: 24 nTPM
  • T-reg: 24 nTPM
  • NK-cell: 22 nTPM
  • memory B-cell: 21 nTPM
  • memory CD8 T-cell: 19 nTPM
  • memory CD4 T-cell: 18 nTPM

Brain region

  • medulla oblongata: 3.7 nTPM
  • spinal cord: 3.7 nTPM
  • choroid plexus: 3.5 nTPM
  • midbrain: 3.4 nTPM
  • basal ganglia: 3.3 nTPM
  • cerebellum: 3.3 nTPM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C10orf143 as an antibody target. Whether an autoantibody or antibody against C10orf143 could matter depends on whether native C10orf143 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C10orf143 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C10orf143 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C10orf143. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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