C10orf126
Putative uncharacterized protein C10orf126
Also known as: CJ126_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for C10orf126 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
172 residues, UniProt reviewed canonical sequence.
>Q8N4M7|C10orf126
1 MNHCIQFSPQ SLQRWLILPC YDLKLPIWAN TTEFCPHGPR RASQDPQLLA WLPDQSLEVS
61 LELYDWNSMT FTLFLETVEP VAVESEGSGI FSFVWQQLIF PAEARWCFSW AQDCGLDGSF
121 PGSAHTEPFG KAAAGQGSVA GKEAKKAGPG FHRQLLYLQF QKRCLFNYPE LLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C10orf126 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.81
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.9
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C10orf126 as an antibody target. Whether an autoantibody or antibody against C10orf126 could matter depends on whether native C10orf126 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C10orf126 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C10orf126 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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