C10orf120
Uncharacterized protein C10orf120
Also known as: bA318C4.1, CJ120_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5SQS8
- Gene
- C10orf120
- Ensembl
- ENSG00000183559
- Chromosome
- 10
- Canonical length
- 335 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for C10orf120 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
335 residues, UniProt reviewed canonical sequence.
>Q5SQS8|C10orf120
1 MIREWKNDCQ RIEKQRASDT MVQERKNEKP VRIFNTNSSF QDQAPTCCQE DLSSASPLRI
61 WSKFYRSDPR IALGKYSPLE KEILRLGGIH TIAARRLLAY KQEEECRMLK ELQLLSPDYK
121 QAMEYKKKHS SPCAICVPLE KIWTAKVIAP LEAFKMPQRE QVNVSKHIER MRLARALGNH
181 QPLPYIERFT RSSFLSGVGL GPMAKNKARR KEDNYDTHNC DDANQDKKEE AEGKNTKRRE
241 IKMNVVFKSK EPKKCLTYHG NDRKSFLPAK KPERSIAGLT NRNLFCISEF PGDLMLMNQD
301 FISRRDHFSD LVKTYSLEEE SIWKERMRKA TPYHYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C10orf120 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.6
- Highest tissue expression
- 29 nTPM
Expression across tissuesHPA
Tissue
- testis: 29 nTPM
- pancreas: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- early spermatids: 809 nCPM
- late spermatids: 159 nCPM
- late primary spermatocytes: 44 nCPM
- peritubular myoid cells: 1.6 nCPM
- leydig cells: 0.8 nCPM
- epididymal basal cells: 0.6 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.9
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.23
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF5520
- Family of unknown function (DUF5520)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C10orf120 as an antibody target. Whether an autoantibody or antibody against C10orf120 could matter depends on whether native C10orf120 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C10orf120 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C10orf120 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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