Seroatlas · Human Serome Atlas

BTN3A2

Butyrophilin subfamily 3 member A2

Also known as: BT3A2_HUMAN, BTN3.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78410
Gene: BTN3A2
Ensembl: ENSG00000186470
Chromosome: 6
Canonical length: 334 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>P78410|BTN3A2
     1  MKMASSLAFL LLNFHVSLLL VQLLTPCSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA
    61  ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD
   121  SGKYLCYFQD GDFYEKALVE LKVAALGSNL HVEVKGYEDG GIHLECRSTG WYPQPQIQWS
   181  NAKGENIPAV EAPVVADGVG LYEVAASVIM RGGSGEGVSC IIRNSLLGLE KTASISIADP
   241  FFRSAQPWIA ALAGTLPILL LLLAGASYFL WRQQKEITAL SSEIESEQEM KEMGYAATER
   301  EISLRESLQE ELKRKKIQYL TRGEESSSDT NKSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTN3A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 83 nTPM

Expression across tissuesHPA

Tissue

spleen: 83 nTPM
lymph node: 43 nTPM
tonsil: 42 nTPM
appendix: 40 nTPM
lung: 39 nTPM
thymus: 36 nTPM

Single-cell type

nk-cells: 124 nCPM
platelets: 115 nCPM
t-cells: 106 nCPM
plasma cells: 102 nCPM
kupffer cells: 73 nCPM
breast lactating cells: 55 nCPM

Immune cell

gdT-cell: 129 nTPM
memory CD8 T-cell: 114 nTPM
T-reg: 112 nTPM
naive CD8 T-cell: 100 nTPM
NK-cell: 99 nTPM
MAIT T-cell: 96 nTPM

Brain region

medulla oblongata: 20 nTPM
white matter: 15 nTPM
spinal cord: 14 nTPM
pons: 13 nTPM
cerebral cortex: 12 nTPM
hypothalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

signaling receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTN3A2 as an antibody target. Whether an autoantibody or antibody against BTN3A2 could matter depends on whether native BTN3A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTN3A2 is annotated at the cell surface, where native BTN3A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BTN3A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...