Seroatlas · Human Serome Atlas

BTG3

Protein BTG3

Also known as: ANA, ANA/BTG3, APRO4, BTG3_HUMAN, tob55

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14201
Gene: BTG3
Ensembl: ENSG00000154640
Chromosome: 21
Canonical length: 252 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

252 residues, UniProt reviewed canonical sequence.

>Q14201|BTG3
     1  MKNEIAAVVF FFTRLVRKHD KLKKEAVERF AEKLTLILQE KYKNHWYPEK PSKGQAYRCI
    61  RVNKFQRVDP DVLKACENSC ILYSDLGLPK ELTLWVDPCE VCCRYGEKNN AFIVASFENK
   121  DENKDEISRK VTRALDKVTS DYHSGSSSSD EETSKEMEVK PSSVTAAASP VYQISELIFP
   181  PLPMWHPLPR KKPGMYRGNG HQNHYPPPVP FGYPNQGRKN KPYRPIPVTW VPPPGMHCDR
   241  NHWINPHMLA PH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 104 nTPM

Expression across tissuesHPA

Tissue

epididymis: 104 nTPM
placenta: 57 nTPM
bone marrow: 53 nTPM
fallopian tube: 49 nTPM
endometrium: 45 nTPM
lung: 45 nTPM

Single-cell type

syncytiotrophoblasts: 2,125 nCPM
cytotrophoblasts: 491 nCPM
epicardial cells: 378 nCPM
respiratory deuterosomal cells: 346 nCPM
early primary spermatocytes: 336 nCPM
pituicytes/fscs: 309 nCPM

Immune cell

T-reg: 32 nTPM
memory CD4 T-cell: 14 nTPM
memory CD8 T-cell: 13 nTPM
MAIT T-cell: 9.4 nTPM
naive CD8 T-cell: 9.1 nTPM
plasmacytoid DC: 8.8 nTPM

Brain region

white matter: 19 nTPM
hypothalamus: 16 nTPM
medulla oblongata: 13 nTPM
spinal cord: 13 nTPM
basal ganglia: 13 nTPM
cerebral cortex: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.92
gnomAD missense Z: 1.86
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTG3 as an antibody target. Whether an autoantibody or antibody against BTG3 could matter depends on whether native BTG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTG3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BTG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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