Seroatlas · Human Serome Atlas

BST1

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

Also known as: BST-1, BST1_HUMAN, cADPR2, CD157

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q10588
Gene: BST1
Ensembl: ENSG00000109743
Chromosome: 4
Canonical length: 318 aa
Protein class: CD markers, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q10588|BST1
     1  MAAQGCAASR LLQLLLQLLL LLLLLAAGGA RARWRGEGTS AHLRDIFLGR CAEYRALLSP
    61  EQRNKNCTAI WEAFKVALDK DPCSVLPSDY DLFINLSRHS IPRDKSLFWE NSHLLVNSFA
   121  DNTRRFMPLS DVLYGRVADF LSWCRQKNDS GLDYQSCPTS EDCENNPVDS FWKRASIQYS
   181  KDSSGVIHVM LNGSEPTGAY PIKGFFADYE IPNLQKEKIT RIEIWVMHEI GGPNVESCGE
   241  GSMKVLEKRL KDMGFQYSCI NDYRPVKLLQ CVDHSTHPDC ALKSAAAATQ RKAPSLYTEQ
   301  RAGLIIPLFL VLASRTQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BST1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 132 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 132 nTPM
duodenum: 46 nTPM
small intestine: 28 nTPM
adipose tissue: 18 nTPM
gallbladder: 17 nTPM
heart muscle: 17 nTPM

Single-cell type

neutrophil progenitors: 225 nCPM
neutrophils: 224 nCPM
enterocytes: 76 nCPM
monocytes: 73 nCPM
monocyte progenitors: 56 nCPM
extravillous trophoblasts: 31 nCPM

Immune cell

neutrophil: 294 nTPM
classical monocyte: 258 nTPM
total PBMC: 110 nTPM
intermediate monocyte: 98 nTPM
myeloid DC: 79 nTPM
non-classical monocyte: 74 nTPM

Brain region

cerebral cortex: 16 nTPM
thalamus: 12 nTPM
white matter: 12 nTPM
pons: 10 nTPM
basal ganglia: 9.9 nTPM
cerebellum: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: -0.1
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BST1 as an antibody target. Whether an autoantibody or antibody against BST1 could matter depends on whether native BST1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BST1 is annotated at the cell surface, where native BST1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BST1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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