BSPH1
Binder of sperm protein homolog 1
Also known as: BSP1, BSPH1_HUMAN, ELSPBP2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q075Z2
- Gene
- BSPH1
- Ensembl
- ENSG00000188334
- Chromosome
- 19
- Canonical length
- 132 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
Predicted to enable heparin binding activity. Predicted to be involved in sperm capacitation. Predicted to be located in extracellular region. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
132 residues, UniProt reviewed canonical sequence.
>Q075Z2|BSPH1
1 MGSLMLLFVE TTRNSSACIF PVILNELSST VETITHFPEV TDGECVFPFH YKNGTYYDCI
61 KSKARHKWCS LNKTYEGYWK FCSAEDFANC VFPFWYRRLI YWECTDDGEA FGKKWCSLTK
121 NFNKDRIWKY CELocalizationUniProt · AlphaFold · HPA
Whether an antibody against BSPH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 361 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 361 nTPM
- retina: 6.9 nTPM
- cerebellum: 0.2 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
Single-cell type
- epididymal principal cells: 273 nCPM
- retinal bipolar cells: 16 nCPM
- retinal pigment epithelial cells: 4.3 nCPM
- epididymal clear cells: 4.1 nCPM
- retinal ganglion cells: 3.9 nCPM
- müller glia: 3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 1.5 nTPM
- midbrain: 0.5 nTPM
- cerebral cortex: 0.4 nTPM
- hypothalamus: 0.2 nTPM
- pons: 0.2 nTPM
- hippocampal formation: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.08
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 0.82
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads BSPH1 as an antibody target. Whether an autoantibody or antibody against BSPH1 could matter depends on whether native BSPH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
BSPH1 is annotated as secreted, so native BSPH1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label BSPH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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