Seroatlas · Human Serome Atlas

BSDC1

BSD domain-containing protein 1

Also known as: BSDC1_HUMAN, FLJ10276, RP4-811H24.7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NW68
Gene: BSDC1
Ensembl: ENSG00000160058
Chromosome: 1
Canonical length: 430 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Plasma membrane

OverviewNCBI Gene

Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

430 residues, UniProt reviewed canonical sequence.

>Q9NW68|BSDC1
     1  MAEGEDVGWW RSWLQQSYQA VKEKSSEALE FMKRDLTEFT QVVQHDTACT IAATASVVKE
    61  KLATEGSSGA TEKMKKGLSD FLGVISDTFA PSPDKTIDCD VITLMGTPSG TAEPYDGTKA
   121  RLYSLQSDPA TYCNEPDGPP ELFDAWLSQF CLEEKKGEIS ELLVGSPSIR ALYTKMVPAA
   181  VSHSEFWHRY FYKVHQLEQE QARRDALKQR AEQSISEEPG WEEEEEELMG ISPISPKEAK
   241  VPVAKISTFP EGEPGPQSPC EENLVTSVEP PAEVTPSESS ESISLVTQIA NPATAPEARV
   301  LPKDLSQKLL EASLEEQGLA VDVGETGPSP PIHSKPLTPA GHTGGPEPRP PARVETLREE
   361  APTDLRVFEL NSDSGKSTPS NNGKKGSSTD ISEDWEKDFD LDMTEEEVQM ALSKVDASGE
   421  LEDVEWEDWE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BSDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 73 nTPM
pancreas: 47 nTPM
liver: 46 nTPM
adrenal gland: 44 nTPM
cerebellum: 40 nTPM
ovary: 40 nTPM

Single-cell type

syncytiotrophoblasts: 151 nCPM
late spermatids: 148 nCPM
early spermatids: 138 nCPM
platelets: 131 nCPM
epididymal principal cells: 116 nCPM
ovarian stromal cells: 106 nCPM

Immune cell

basophil: 37 nTPM
eosinophil: 18 nTPM
naive B-cell: 8.3 nTPM
neutrophil: 8.3 nTPM
T-reg: 7.3 nTPM
memory B-cell: 6.9 nTPM

Brain region

white matter: 55 nTPM
medulla oblongata: 51 nTPM
cerebellum: 48 nTPM
cerebral cortex: 44 nTPM
hippocampal formation: 42 nTPM
pons: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.02
gnomAD missense Z: 0.63
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BSDC1 as an antibody target. Whether an autoantibody or antibody against BSDC1 could matter depends on whether native BSDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BSDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BSDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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