Seroatlas · Human Serome Atlas

BRINP3

BMP/retinoic acid-inducible neural-specific protein 3

Also known as: BRNP3_HUMAN, DBCCR1L, DBCCR1L1, FAM5C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q76B58
Gene: BRINP3
Ensembl: ENSG00000162670
Chromosome: 1
Canonical length: 766 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

766 residues, UniProt reviewed canonical sequence.

>Q76B58|BRINP3
     1  MIWRSRAGAE LFSLMALWEW IALSLHCWVL AVAAVSDQHA TSPFDWLLSD KGPFHRSQEY
    61  TDFVDRSRQG FSTRYKIYRE FGRWKVNNLA VERRNFLGSP LPLAPEFFRN IRLLGRRPTL
   121  QQITENLIKK YGTHFLLSAT LGGEESLTIF VDKRKLSKRA EGSDSTTNSS SVTLETLHQL
   181  AASYFIDRDS TLRRLHHIQI ASTAIKVTET RTGPLGCSNY DNLDSVSSVL VQSPENKIQL
   241  QGLQVLLPDY LQERFVQAAL SYIACNSEGE FICKENDCWC HCGPKFPECN CPSMDIQAME
   301  ENLLRITETW KAYNSDFEES DEFKLFMKRL PMNYFLNTST IMHLWTMDSN FQRRYEQLEN
   361  SMKQLFLKAQ KIVHKLFSLS KRCHKQPLIS LPRQRTSTYW LTRIQSFLYC NENGLLGSFS
   421  EETHSCTCPN DQVVCTAFLP CTVGDASACL TCAPDNRTRC GTCNTGYMLS QGLCKPEVAE
   481  STDHYIGFET DLQDLEMKYL LQKTDRRIEV HAIFISNDMR LNSWFDPSWR KRMLLTLKSN
   541  KYKSSLVHMI LGLSLQICLT KNSTLEPVLA VYVNPFGGSH SESWFMPVNE NSFPDWERTK
   601  LDLPLQCYNW TLTLGNKWKT FFETVHIYLR SRIKSNGPNG NESIYYEPLE FIDPSRNLGY
   661  MKINNIQVFG YSMHFDPEAI RDLILQLDYP YTQGSQDSAL LQLLEIRDRV NKLSPPGQRR
   721  LDLFSCLLRH RLKLSTSEVV RIQSALQAFN AKLPNTMDYD TTKLCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRINP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 25 nTPM
small intestine: 17 nTPM
hypothalamus: 12 nTPM
amygdala: 11 nTPM
basal ganglia: 9.2 nTPM
cerebellum: 7.7 nTPM

Single-cell type

oligodendrocyte progenitor cells: 1,626 nCPM
other brain neurons: 519 nCPM
bergmann glia: 506 nCPM
brain excitatory neurons: 389 nCPM
astrocytes: 375 nCPM
prostatic glandular cells: 374 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 62 nTPM
hypothalamus: 60 nTPM
basal ganglia: 47 nTPM
cerebellum: 45 nTPM
midbrain: 40 nTPM
spinal cord: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.15
gnomAD missense Z: 0.19
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRINP3 as an antibody target. Whether an autoantibody or antibody against BRINP3 could matter depends on whether native BRINP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRINP3 is annotated as secreted, so native BRINP3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label BRINP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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