Seroatlas · Human Serome Atlas

BRINP2

BMP/retinoic acid-inducible neural-specific protein 2

Also known as: BRNP2_HUMAN, DBCCR1L2, FAM5B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9C0B6
Gene
BRINP2
Ensembl
ENSG00000198797
Chromosome
1
Canonical length
783 aa
Protein class
Predicted secreted proteins, Transporters
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Predicted to be involved in cellular response to retinoic acid; central nervous system neuron differentiation; and negative regulation of mitotic cell cycle. Predicted to act upstream of or within locomotion and nervous system development. Predicted to be located in extracellular region. Predicted to be active in cytoplasm; dendrite; and neuronal cell body. Implicated in oral squamous cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

783 residues, UniProt reviewed canonical sequence.

>Q9C0B6|BRINP2
     1  MRWQCGTRFR GLRPAVAPWT ALLALGLPGW VLAVSATAAA VVPEQHASVA GQHPLDWLLT
    61  DRGPFHRAQE YADFMERYRQ GFTTRYRIYR EFARWKVNNL ALERKDFFSL PLPLAPEFIR
   121  NIRLLGRRPN LQQVTENLIK KYGTHFLLSA TLGGEESLTI FVDKQKLGRK TETTGGASII
   181  GGSGNSTAVS LETLHQLAAS YFIDRESTLR RLHHIQIATG AIKVTETRTG PLGCSNYDNL
   241  DSVSSVLVQS PENKVQLLGL QVLLPEYLRE RFVAAALSYI TCSSEGELVC KENDCWCKCS
   301  PTFPECNCPD ADIQAMEDSL LQIQDSWATH NRQFEESEEF QALLKRLPDD RFLNSTAISQ
   361  FWAMDTSLQH RYQQLGAGLK VLFKKTHRIL RRLFNLCKRC HRQPRFRLPK ERSLSYWWNR
   421  IQSLLYCGES TFPGTFLEQS HSCTCPYDQS SCQGPIPCAL GEGPACAHCA PDNSTRCGSC
   481  NPGYVLAQGL CRPEVAESLE NFLGLETDLQ DLELKYLLQK QDSRIEVHSI FISNDMRLGS
   541  WFDPSWRKRM LLTLKSNKYK PGLVHVMLAL SLQICLTKNS TLEPVMAIYV NPFGGSHSES
   601  WFMPVNEGSF PDWERTNVDA AAQCQNWTIT LGNRWKTFFE TVHVYLRSRI KSLDDSSNET
   661  IYYEPLEMTD PSKNLGYMKI NTLQVFGYSL PFDPDAIRDL ILQLDYPYTQ GSQDSALLQL
   721  IELRDRVNQL SPPGKVRLDL FSCLLRHRLK LANNEVGRIQ SSLRAFNSKL PNPVEYETGK
   781  LCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRINP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 27 nTPM
  • amygdala: 19 nTPM
  • basal ganglia: 13 nTPM
  • hippocampal formation: 11 nTPM
  • hypothalamus: 9.6 nTPM
  • adrenal gland: 8.5 nTPM

Single-cell type

  • astrocytes: 176 nCPM
  • oligodendrocyte progenitor cells: 140 nCPM
  • pituitary stem cells: 117 nCPM
  • brain excitatory neurons: 113 nCPM
  • brain inhibitory neurons: 76 nCPM
  • adrenal medulla cells: 75 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 47 nTPM
  • amygdala: 41 nTPM
  • thalamus: 39 nTPM
  • basal ganglia: 33 nTPM
  • white matter: 32 nTPM
  • hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
1
gnomAD missense Z
0.86
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRINP2 as an antibody target. Whether an autoantibody or antibody against BRINP2 could matter depends on whether native BRINP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRINP2 is annotated as secreted, so native BRINP2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label BRINP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BRINP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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