Seroatlas · Human Serome Atlas

BRICD5

BRICHOS domain-containing protein 5

Also known as: BRID5_HUMAN, C16orf79, MGC21830

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PL45
Gene: BRICD5
Ensembl: ENSG00000182685
Chromosome: 16
Canonical length: 260 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Actin filaments

OverviewNCBI Gene

Predicted to be involved in regulation of cell population proliferation. Predicted to be located in membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

260 residues, UniProt reviewed canonical sequence.

>Q6PL45|BRICD5
     1  MEPASCCAER PKPGPTGVKT KPSCGGWRAV SLLLLLLLLV LAAVGVVAGG LLGSAQGPPK
    61  PRLQTLRMTL PSPHMPRPNQ TILVDVARNA ATITVTPPQS NHSWAVLFDG QSGCICYRPE
   121  EHQVCFLRLM EDSDRETLRL LVDTSKVQEA WVPSQDTHHT QELLAVQGSL EVDPAQAGAL
   181  VQRLCMRTPI YWARRAEGES GPLWGKARPS GWFEELGAEP LEIHGTLATG PRRQRLIYLC
   241  IDICFPSNIC VSVCFYYLPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRICD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 119 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 119 nTPM
thyroid gland: 27 nTPM
cerebral cortex: 27 nTPM
testis: 23 nTPM
basal ganglia: 22 nTPM
hypothalamus: 21 nTPM

Single-cell type

sertoli cells: 19 nCPM
late spermatids: 15 nCPM
cone photoreceptor cells: 10 nCPM
retinal amacrine cells: 8.8 nCPM
astrocytes: 8.6 nCPM
brain excitatory neurons: 7.7 nCPM

Immune cell

eosinophil: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
neutrophil: 0.2 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

cerebellum: 64 nTPM
cerebral cortex: 35 nTPM
medulla oblongata: 27 nTPM
pons: 26 nTPM
white matter: 24 nTPM
thalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: -1.93
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of cell population proliferation

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRICD5 as an antibody target. Whether an autoantibody or antibody against BRICD5 could matter depends on whether native BRICD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRICD5 is annotated as secreted, so native BRICD5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label BRICD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...