Seroatlas · Human Serome Atlas

BRD3OS

Uncharacterized protein BRD3OS

Also known as: bA374P20.3, BRDOS_HUMAN, FLJ35348, LINC00094, NCRNA00094, SERLOC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GUI7
Gene
BRD3OS
Ensembl
ENSG00000235106
Chromosome
9
Canonical length
84 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Vesicles,Cytosol

OverviewNCBI Gene

No narrative summary is available for BRD3OS in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

84 residues, UniProt reviewed canonical sequence.

>A0A1B0GUI7|BRD3OS
     1  MSGRVPLAEK ALSEGYARLR YRDTSLLIWQ QQQQKLESVP PGTYLSRSRS MWYSQYGNEA
    61  ILVRDKNKLE VSRDTGQSKF CTIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRD3OS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 35 nTPM
  • amygdala: 29 nTPM
  • retina: 28 nTPM
  • basal ganglia: 28 nTPM
  • hippocampal formation: 27 nTPM
  • pituitary gland: 26 nTPM

Single-cell type

  • platelets: 83 nCPM
  • late spermatids: 49 nCPM
  • respiratory ciliated cells: 47 nCPM
  • fallopian tube ciliated cells: 41 nCPM
  • late primary spermatocytes: 32 nCPM
  • differentiating spermatogonia: 30 nCPM

Immune cell

  • naive B-cell: 14 nTPM
  • naive CD4 T-cell: 13 nTPM
  • memory CD4 T-cell: 13 nTPM
  • memory B-cell: 13 nTPM
  • gdT-cell: 12 nTPM
  • memory CD8 T-cell: 12 nTPM

Brain region

  • hippocampal formation: 47 nTPM
  • thalamus: 47 nTPM
  • cerebral cortex: 45 nTPM
  • midbrain: 45 nTPM
  • amygdala: 44 nTPM
  • basal ganglia: 44 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRD3OS as an antibody target. Whether an autoantibody or antibody against BRD3OS could matter depends on whether native BRD3OS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRD3OS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BRD3OS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BRD3OS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...