Seroatlas · Human Serome Atlas

BRD10

Uncharacterized bromodomain-containing protein 10

Also known as: BRD10_HUMAN, FLJ20375, KIAA2026

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5HYC2
Gene: BRD10
Ensembl: ENSG00000183354
Chromosome: 9
Canonical length: 2103 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2103 residues, UniProt reviewed canonical sequence.

>Q5HYC2|BRD10
     1  MSVPGTPGAM EPAGEEERPP PAAEGEDDEE EVAAAAQTSG PAHGRSASSL EDADDQEEEM
    61  EAMVIGGGCC KEQELTYELQ QGYRILGEFL QEKHRGLTAP FLQPLGGVAT AEEEVAEGPR
   121  SGGRGGRAFP QQPGQGMCLL QMEEKFASGQ YGGITEFVAD FRLMLETCYR LHGVDHWISK
   181  QGQKLEMMLE QKLALLSRHL REKTTIAVTS RGYYGLEDEK GTACTSTRRR STPRSLAGLT
   241  SGVFESIMVQ VLRQEEQLRA KEEKRLREQE RKEAEEASQK EIEEWERKLL AQAAPTCMET
   301  MWEIPAIGHF LCLAQQILNL PEIVFYELER CLLMPQCNAF LSKIMTSLLS PPHRRPTLHR
   361  RPTLPYRTWE AALRQKVQQW YTAVGQTENP DNCAEKLGLC PQFFKVLGEV NPLEEKPFHE
   421  LPFYQKVWLL KGLCDFVYET QKEVQDAVLG QPIHECREVI LGYDYLENAY VHFPQFCGAD
   481  VRIYKQRPFQ APEFPIPPIK IQRVPRIKLE KLKCDYVSTS NGEHRCSRDS LPSSFKKEQE
   541  NNFDPACCPA KMILDNHDIS VEMGVKSNYE IRIRRPCEIK KTDCCKENLE KPRSPGEVTG
   601  FGEPLSPGEI RFIENQEKYG EASRIKIEPS PLKENTLKSC QIHVNGSHSD HPEINCHKVV
   661  RDILLEQSLQ SHKKLKLTKM RAKKKKKKKK KLKDVLNENL QRKREGLHSL AFKSYKPEIQ
   721  NKLLIIKKKA KHKKHKSGKK SVSKKAITKK RKTVIKSPTV PEFQLICTNL DELRELITKI
   781  ENELKDLENS RKKSGKWYHR RQAVKELHST LIRLLNELLP WEPKLMKAFQ RNRSRLKKDY
   841  DDFRRQPDHD TFNRELWTTD EGEGDLGKDS PKGEISKSID STEPLDILEK DHFDSDDMKL
   901  SEIDFPMARS KLLKKELPSK DLPKTLLKTL KRQSKQTDYV DDSTKELSPR KKAKLSTNET
   961  TVENLESDVQ IDCFSESKHT EPSFPESFAS LDSVPVSTLQ KGTKPIQALL AKNIGNKVTL
  1021  TNQLPPSTGR NALAVEKPVL SPPEASPIKP ALTCHTNTKG PLQMVYKMPC GQWLPIDLQN
  1081  SSVKIQVQPM VDPKTGEKIM QQVLILPKNF VIQHKEGKAV AKEVPPLQQK GTEQHCSSFP
  1141  QTTNINSSLA SVFVNSPGTV STQLPNTAFN KTITPLSNIS SARPQPLSPV TSVSNLLTPS
  1201  VKTSQSEAGK AKNAVSAATF SLPSASPTIS STGQPLSSTT TLNGSTNPGS SFNCFAQQTA
  1261  DSSEAKQELK TVCIRDSQSI LVRTRGGNTG VVKVQTNPDQ NSPNTVSSSS VFTFAPQLQA
  1321  FLVPKSTTSS SAFSPVAGTT TTSSLSPFSQ TPTSVSIPAS FAPSMGKNLK LTLGHTTGSG
  1381  DLGHVIDKTS HMPSSPLKSS ICSSTLLPST TSSSVSVISI SAANFGQNNA NIIHTPTKQQ
  1441  QVDYITKSYP VTRSEATAAT NGDVISGTPV QKLMLVSAPS ILSSGNGTAI NMTPALTSTG
  1501  VSAQKLVFIN APVPSGTSTP TLVAESLKQT LPPPLHKAYV KTPEQPQIVL IPSTVGTPIK
  1561  INSSPAVSQI KDVKIGLNIG QAIVNTSGTV PAIPSINILQ NVTPKGEDKS SKGYILPLST
  1621  SGNSVPVSSN FVSQNITPVN ESVVSSARAV NVLSVTGANL SLGSFPVTSA SASAGAQPPV
  1681  LVSGNDTSSR IMPILSNRLC SSSLGNTVAI STVKTGHLAS SVLISTTQPV VSPKCLTSAL
  1741  QIPVTVALPT PATTSPKIIN TVPHSAAVPG ATRSVSISKR QSRTSLQFHS PGISTTVPTN
  1801  VNTNKPQTEL SSLSTSPGKI TNTSNFASLP NQQALVKTPS YSSAPGGTTI HTASAPSNVT
  1861  SLVGSQFSEP CIQQKIVINT STPLAPGTQI MINGTRFIVP PQGLGAGSHV LLISTNPKYG
  1921  APLVLNSGQG IQSTPIDNSA QKITLASNNS LSGQPLQHPL RSPTKFINSF GNASSIPTVH
  1981  TSPQLINTTA KVPVPPPVPT VSLTSVIKSP ATLLAKTSLV SAICPSNPPL PSSTSVFHLD
  2041  PPVKKLLVSP EGAILNTINT PASKVSSLSP SLSQIVVSAS RSPASVFPAF QSSGLEKPDR
  2101  AAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
retina: 9.6 nTPM
skeletal muscle: 8.9 nTPM
spinal cord: 8.9 nTPM
tongue: 8.8 nTPM
cerebral cortex: 8.5 nTPM

Single-cell type

choroid plexus epithelial cells: 1,520 nCPM
thyrotrophs: 274 nCPM
melanocytes: 242 nCPM
neutrophils: 241 nCPM
neutrophil progenitors: 238 nCPM
lactotrophs: 234 nCPM

Immune cell

eosinophil: 7 nTPM
neutrophil: 6 nTPM
memory B-cell: 5.9 nTPM
basophil: 5.1 nTPM
naive CD8 T-cell: 4.9 nTPM
NK-cell: 4.9 nTPM

Brain region

choroid plexus: 69 nTPM
cerebellum: 66 nTPM
basal ganglia: 51 nTPM
white matter: 51 nTPM
amygdala: 44 nTPM
midbrain: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.66

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Bromodomain
Bromodomain-like superfamily
Bromodomain
Uncharacterized bromodomain-containing protein 10
Uncharacterized bromodomain-containing protein 10, helical domain
KIAA2026 helical domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRD10 as an antibody target. Whether an autoantibody or antibody against BRD10 could matter depends on whether native BRD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRD10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BRD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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