Seroatlas · Human Serome Atlas

BPY2

Testis-specific basic protein Y 2

Also known as: BPY2A, BPY2B, BPY2C, VCY2, VCY2_HUMAN, VCY2A, VCY2B, VCY2C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14599
Gene
BPY2
Ensembl
ENSG00000183753
Chromosome
Y
Canonical length
106 aa
Protein class
Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palidromic region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

106 residues, UniProt reviewed canonical sequence.

>O14599|BPY2
     1  MMTLVPRART RAGQDHYSHP CPRFSQVLLT EGIMTYCLTK NLSDVNILHR LLKNGNVRNT
    61  LLQSKVGLLT YYVKLYPGEV TLLTRPSIQM RLCCITGSVS RPRSQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BPY2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
1.1 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.1 nTPM
  • gallbladder: 0.1 nTPM
  • kidney: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Molecular functions

  • HECT domain binding

Cellular components

InteractionsUniProt · HPA

Protein binding partners of BPY2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BPY2 as an antibody target. Whether an autoantibody or antibody against BPY2 could matter depends on whether native BPY2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BPY2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BPY2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BPY2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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