BPIFB1

Protein identityUniProt · HPA

UniProt accession

Q8TDL5

Gene

BPIFB1

Ensembl

ENSG00000125999

Chromosome

20

Canonical length

484 aa

Protein class

Plasma proteins, Predicted secreted proteins

Secretome location

Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

484 residues, UniProt reviewed canonical sequence.

>Q8TDL5|BPIFB1
     1  MAGPWTFTLL CGLLAATLIQ ATLSPTAVLI LGPKVIKEKL TQELKDHNAT SILQQLPLLS
    61  AMREKPAGGI PVLGSLVNTV LKHIIWLKVI TANILQLQVK PSANDQELLV KIPLDMVAGF
   121  NTPLVKTIVE FHMTTEAQAT IRMDTSASGP TRLVLSDCAT SHGSLRIQLL HKLSFLVNAL
   181  AKQVMNLLVP SLPNLVKNQL CPVIEASFNG MYADLLQLVK VPISLSIDRL EFDLLYPAIK
   241  GDTIQLYLGA KLLDSQGKVT KWFNNSAASL TMPTLDNIPF SLIVSQDVVK AAVAAVLSPE
   301  EFMVLLDSVL PESAHRLKSS IGLINEKAAD KLGSTQIVKI LTQDTPEFFI DQGHAKVAQL
   361  IVLEVFPSSE ALRPLFTLGI EASSEAQFYT KGDQLILNLN NISSDRIQLM NSGIGWFQPD
   421  VLKNIITEII HSILLPNQNG KLRSGVPVSL VKALGFEAAE SSLTKDALVL TPASLWKPSS
   481  PVSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BPIFB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

532 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for BPIFB1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.96

gnomAD pLI

0

gnomAD missense Z

0.63

DepMap mean gene effect

-0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• innate immune response in mucosa
• negative regulation of toll-like receptor 4 signaling pathway

Molecular functions

• lipid binding

Cellular components

• extracellular exosome
• extracellular region

Protein domainsUniProt · Pfam · InterPro

• Lipid-binding serum glycoprotein, C-terminal
• Lipid-binding serum glycoprotein, N-terminal
• Bactericidal permeability-increasing protein, alpha/beta domain superfamily
• LBP / BPI / CETP family, N-terminal domain
• LBP / BPI / CETP family, C-terminal domain
• BPI fold-containing family B member 1

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Immunity
• Innate immunity
• Secreted
• Signal