Seroatlas · Human Serome Atlas

BPIFA4P

Putative BPIFA4P protein

Also known as: LATH_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YQ2
Gene: BPIFA4P
Canonical length: 179 aa

OverviewNCBI Gene

No narrative summary is available for BPIFA4P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

179 residues, UniProt reviewed canonical sequence.

>Q86YQ2|BPIFA4P
     1  MLNVSGLFVL LCGLLVSSSA QEVLAGVSSQ LLNDLTQGLL RADFLPSLQT TGLQKPLSSA
    61  FDGVSGLLDI FGPPLTNEIN TVSIQVKNPQ LLHVSIESTP QRKEATVQVP FTSELIVQLL
   121  TMKPFTANMQ SDIKVQIRLE KNVGGRYELA FGNCRLLPEA IWIQTGVQLA PAQNLLWQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BPIFA4P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BPIFA4P as an antibody target. Whether an autoantibody or antibody against BPIFA4P could matter depends on whether native BPIFA4P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BPIFA4P is annotated as secreted, so native BPIFA4P circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label BPIFA4P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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